A combinatorial library of 125 chiral Schiff base ligands 5 was synthesized with the use of solution-phase parallel synthesis and solid-phase extraction (SPE) techniques to scavenge excess reagents and reaction by-products and avoid chromatography. The synthetic methodology coupled five N-Boc-protected beta -amino sulfonyl chlorides 1a-e with five different amines 2 f-j to give 25 N-Boc sulfonamides 3, which were in turn deprotected and coupled with five salicylaldehydes 4p-t to give 125 ligands 5 in good yields and of sufficient purity to be used in ligand-catalyzed reactions. These ligands were tested in the copper-catalyzed conjugate addition of dialkyl zinc to cyclic and acyclic enones, A multisubstrate high throughput screening of the library was performed with an equimolar mixture of 2-cyclohexenone and 2-cycloheptenone (9 and 10, respectively, 0.2 mmol total), with 5.5 mol% ligand 5 (0.011 mmol) and 5 mol % Cu(OTf)(2) (OTf = OSO2CF3) (0.010 mmol) in 1:1 toluene/hexane at - 20 degreesC From the screening of the library, 5bhr was identified as the best ligand, which yielded 3-ethylcyclohexanone (12) and 3-ethylcycloheptanone (13) in 82% and 81% cc, respectively, and complete conversions. Under optimized conditions (2.75 mol% 5bhr, 2.5 mol% copper(t) triflate, toluene as reaction solvent), improved results were obtained for 12 (90% cc, 93% yield) and for 13 (91% cc, 95% yield). Selected ligands 5 were also tested in the addition of Me2Zn to 2-cyclohexenone (9, cc up to 79%). of Et2Zn to 2-cyclopentenone (11, cc up to 80%) and to acyclic enones 16 and 17 (ce up to 50%).

Discovery of a new efficient chiral ligand for copper-catalyzed enantioselective Michael additions by high-throughput screening of a parallel library / I. Chataigner, C. Gennari, S. Ongeri, U. Piarulli, S. Ceccarelli. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 7:12(2001), pp. 2628-2634.

Discovery of a new efficient chiral ligand for copper-catalyzed enantioselective Michael additions by high-throughput screening of a parallel library

C. Gennari
Secondo
;
2001

Abstract

A combinatorial library of 125 chiral Schiff base ligands 5 was synthesized with the use of solution-phase parallel synthesis and solid-phase extraction (SPE) techniques to scavenge excess reagents and reaction by-products and avoid chromatography. The synthetic methodology coupled five N-Boc-protected beta -amino sulfonyl chlorides 1a-e with five different amines 2 f-j to give 25 N-Boc sulfonamides 3, which were in turn deprotected and coupled with five salicylaldehydes 4p-t to give 125 ligands 5 in good yields and of sufficient purity to be used in ligand-catalyzed reactions. These ligands were tested in the copper-catalyzed conjugate addition of dialkyl zinc to cyclic and acyclic enones, A multisubstrate high throughput screening of the library was performed with an equimolar mixture of 2-cyclohexenone and 2-cycloheptenone (9 and 10, respectively, 0.2 mmol total), with 5.5 mol% ligand 5 (0.011 mmol) and 5 mol % Cu(OTf)(2) (OTf = OSO2CF3) (0.010 mmol) in 1:1 toluene/hexane at - 20 degreesC From the screening of the library, 5bhr was identified as the best ligand, which yielded 3-ethylcyclohexanone (12) and 3-ethylcycloheptanone (13) in 82% and 81% cc, respectively, and complete conversions. Under optimized conditions (2.75 mol% 5bhr, 2.5 mol% copper(t) triflate, toluene as reaction solvent), improved results were obtained for 12 (90% cc, 93% yield) and for 13 (91% cc, 95% yield). Selected ligands 5 were also tested in the addition of Me2Zn to 2-cyclohexenone (9, cc up to 79%). of Et2Zn to 2-cyclopentenone (11, cc up to 80%) and to acyclic enones 16 and 17 (ce up to 50%).
Settore CHIM/06 - Chimica Organica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175385
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 61
  • ???jsp.display-item.citation.isi??? 59
social impact