The optimal ligand 1 for the enantioselective copper-catalyzed 1,4-addition of Et2Zn to cyclic enones [Eq. (1)] was established by multisubstrate (high-throughput) screening of a parallel library of chiral Schiff base ligands. The screening data show how the ligand structure is finely tuned by mutual influences of stereogenic center a (which controls the absolute configuration of the reaction product), stereogenic center b, and the substitution pattern of the aromatic ring. Tf=F3CSO2.

Discovery of a new efficient chiral ligand for copper-catalyzed enantioselective Michael additions by high-throughput screening of a parallel library / I. Chataigner, C.M.A. Gennari, U. Piarulli, S. Ceccarelli. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 39:5(2000 Mar 03), pp. 916-918.

Discovery of a new efficient chiral ligand for copper-catalyzed enantioselective Michael additions by high-throughput screening of a parallel library

C.M.A. Gennari
Secondo
;
2000

Abstract

The optimal ligand 1 for the enantioselective copper-catalyzed 1,4-addition of Et2Zn to cyclic enones [Eq. (1)] was established by multisubstrate (high-throughput) screening of a parallel library of chiral Schiff base ligands. The screening data show how the ligand structure is finely tuned by mutual influences of stereogenic center a (which controls the absolute configuration of the reaction product), stereogenic center b, and the substitution pattern of the aromatic ring. Tf=F3CSO2.
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175381
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