One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.
Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice / A. Balsari, C. Rumio, D. Morelli, L. Sfondrini, E. Nardini, I. Barajon, S. Ménard. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 85:12(2001 Dec 14), pp. 1964-1967.
Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
A. BalsariPrimo
;C. RumioSecondo
;L. Sfondrini;I. BarajonPenultimo
;
2001
Abstract
One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.
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