One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.

Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice / A. Balsari, C. Rumio, D. Morelli, L. Sfondrini, E. Nardini, I. Barajon, S. Ménard. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 85:12(2001 Dec 14), pp. 1964-1967.

Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice

A. Balsari
Primo
;
C. Rumio
Secondo
;
L. Sfondrini;I. Barajon
Penultimo
;
2001

Abstract

One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.
Antidotal activity; Apoptosis; Doxorubicin; Monoclonal antibody; Mucositis
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175343
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