The hydrolysis at pH 7.5 in the presence of immobilized benzylpenicillin acylase of the N-phenacetyl derivatives of the primary amines ()-() affords the hydroxy amines ()-(), key intermediates in the synthesis of optically active forms of carnitin and propranalol, of 0.4, 0.3 and 0.8 , respectively. The hydrolysis at pH 7.5 and 28 °C of the N-phenacetyl derivatives (3)–(5) in the presence of immobilized benzylpenicillin acylase affords the amines (6)–(8) and the amides (9)–(11)
Immobilized benzylpenicillin acylase : application to the synthesis of optically active forms of carnitine and propranolol / C. Fuganti, P. Grasselli, P. Seneci, S. Servi, P. Casati. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 27:18(1986), pp. 2061-2062.
Immobilized benzylpenicillin acylase : application to the synthesis of optically active forms of carnitine and propranolol
P. Seneci;
1986
Abstract
The hydrolysis at pH 7.5 in the presence of immobilized benzylpenicillin acylase of the N-phenacetyl derivatives of the primary amines ()-() affords the hydroxy amines ()-(), key intermediates in the synthesis of optically active forms of carnitin and propranalol, of 0.4, 0.3 and 0.8 , respectively. The hydrolysis at pH 7.5 and 28 °C of the N-phenacetyl derivatives (3)–(5) in the presence of immobilized benzylpenicillin acylase affords the amines (6)–(8) and the amides (9)–(11)
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