The synthesis of a number of novel simplified eleutheside analogues with potent tubulin-assembling and microtubulestabilizing properties is described, using ring-closing metathesis as the key-step for obtaining the 6-10 fused bicyclic ring system. (C) 2003 Elsevier Science Ltd. All rights reserved.

Synthesis of novel simplified eleutheside analogues with potent microtubule-stabilizing activity, using ring-closing metathesis as the key-step / R. Beumer, J.P. Bayon Rueda, P. Bugada, S. Ducki, N. Mongelli, F. Sirtori, J. Telser, C.M.A. Gennari. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 44:4(2003 Jan 20), pp. 681-684.

Synthesis of novel simplified eleutheside analogues with potent microtubule-stabilizing activity, using ring-closing metathesis as the key-step

J.P. Bayon Rueda
Secondo
;
C.M.A. Gennari
Ultimo
2003

Abstract

The synthesis of a number of novel simplified eleutheside analogues with potent tubulin-assembling and microtubulestabilizing properties is described, using ring-closing metathesis as the key-step for obtaining the 6-10 fused bicyclic ring system. (C) 2003 Elsevier Science Ltd. All rights reserved.
allylation ; antitumour compounds ; metathesis ; stereocontrol
Settore CHIM/06 - Chimica Organica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175268
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