Preliminary studies were conducted on the implementation of a new strategy to the total synthesis OC the common diterpenoid tricyclic skeleton of sarcodictyins and eleutherobin. According to the approach presented, a key retrosynthetic disconnection is devised at the C3-C5 position, identifying a carbonylative cross-coupling reaction as the medium-sized ring forming step. The synthesis of a fully functionalized cyclization precursor, comprising a Z vinylstannane and a carboalkoxy-substituted Z enol triflate as reactive centres is described. (C) 2001 Elsevier Science Ltd. All rights reserved.

A carbonylative cross-coupling strategy to the total synthesis of the sarcodictyins : preliminary studies and synthesis of a cyclization precursor / S. Ceccarelli, U. Piarulli, J. Telser, C.M.A. Gennari. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 42:42(2001), pp. 7421-7425.

A carbonylative cross-coupling strategy to the total synthesis of the sarcodictyins : preliminary studies and synthesis of a cyclization precursor

C.M.A. Gennari
Ultimo
2001

Abstract

Preliminary studies were conducted on the implementation of a new strategy to the total synthesis OC the common diterpenoid tricyclic skeleton of sarcodictyins and eleutherobin. According to the approach presented, a key retrosynthetic disconnection is devised at the C3-C5 position, identifying a carbonylative cross-coupling reaction as the medium-sized ring forming step. The synthesis of a fully functionalized cyclization precursor, comprising a Z vinylstannane and a carboalkoxy-substituted Z enol triflate as reactive centres is described. (C) 2001 Elsevier Science Ltd. All rights reserved.
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175235
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