The synthesis of a series of cyclooctadiene anhydrides, analogs of the natural compd. zopfiellin, was performed to assay their in vitro and in vivo antifungal activity on a set of plant pathogenic fungi. Most of the synthesized compds. possessed a broad spectrum of activity. In particular, the anhydrides 2 and 5a were very effective against the Oomycete diseases such as Phytophthora infestans and Pythium ultimum, reaching a level of activity well comparable with that of com. fungicides in use. Preliminary in vivo evaluation of their protectant activity is also reported.
Natural products as sources of new fungicides : synthesis and antifungal activity of zopfiellin analogues / L. Musso, S. Dallavalle, G. Farina, E. Burrone. - In: CHEMICAL BIOLOGY & DRUG DESIGN. - ISSN 1747-0277. - 79:5(2012), pp. 780-789. [10.1111/j.1747-0285.2012.01343.x]
Natural products as sources of new fungicides : synthesis and antifungal activity of zopfiellin analogues
L. MussoPrimo
;S. DallavalleSecondo
;G. FarinaPenultimo
;E. BurroneUltimo
2012
Abstract
The synthesis of a series of cyclooctadiene anhydrides, analogs of the natural compd. zopfiellin, was performed to assay their in vitro and in vivo antifungal activity on a set of plant pathogenic fungi. Most of the synthesized compds. possessed a broad spectrum of activity. In particular, the anhydrides 2 and 5a were very effective against the Oomycete diseases such as Phytophthora infestans and Pythium ultimum, reaching a level of activity well comparable with that of com. fungicides in use. Preliminary in vivo evaluation of their protectant activity is also reported.Pubblicazioni consigliate
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