Introduction Melatonin could be useful in critically ill thanks to its antioxidant, immunomodulating, and hypnagogue effects. When administered orally, its bioavailability is limited by a marked first pass hepatic metabolism. Incorporation in SLN, targeted to lymph after enteral administration may create a sustained release delivery system. This could maintain a prolonged blood concentration, and allow cellular internalization independent from MT1/MT2 membrane receptors.
Pharmacokinetics of oral melatonin in high-risk critically ill : standard formulation vs incapsulation in solid lipid nanoparticles (SLN) / B. Salihovic, F. Ferrari, G. Mistraletti, E. Mantovani, R.C. Paroni, E. Finati, F.L. Fraschini, I. Galluccio, B. Cerri, S. Marzorati, G. Iapichino. ((Intervento presentato al 23. convegno SMART tenutosi a Milano nel 2012.
Pharmacokinetics of oral melatonin in high-risk critically ill : standard formulation vs incapsulation in solid lipid nanoparticles (SLN)
G. Mistraletti;E. Mantovani;R.C. Paroni;E. Finati;F.L. Fraschini;G. Iapichino
2012
Abstract
Introduction Melatonin could be useful in critically ill thanks to its antioxidant, immunomodulating, and hypnagogue effects. When administered orally, its bioavailability is limited by a marked first pass hepatic metabolism. Incorporation in SLN, targeted to lymph after enteral administration may create a sustained release delivery system. This could maintain a prolonged blood concentration, and allow cellular internalization independent from MT1/MT2 membrane receptors.File | Dimensione | Formato | |
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