Introduction Melatonin could be useful in critically ill thanks to its antioxidant, immunomodulating, and hypnagogue effects. When administered orally, its bioavailability is limited by a marked first pass hepatic metabolism. Incorporation in SLN, targeted to lymph after enteral administration may create a sustained release delivery system. This could maintain a prolonged blood concentration, and allow cellular internalization independent from MT1/MT2 membrane receptors.

Pharmacokinetics of oral melatonin in high-risk critically ill : standard formulation vs incapsulation in solid lipid nanoparticles (SLN) / B. Salihovic, F. Ferrari, G. Mistraletti, E. Mantovani, R.C. Paroni, E. Finati, F.L. Fraschini, I Galluccio, B. Cerri, S. Marzorati, G. Iapichino. ((Intervento presentato al 23. convegno SMART tenutosi a Milano nel 2012.

Pharmacokinetics of oral melatonin in high-risk critically ill : standard formulation vs incapsulation in solid lipid nanoparticles (SLN)

G. Mistraletti;E. Mantovani;R.C. Paroni;E. Finati;F.L. Fraschini;G. Iapichino
2012-05

Abstract

Introduction Melatonin could be useful in critically ill thanks to its antioxidant, immunomodulating, and hypnagogue effects. When administered orally, its bioavailability is limited by a marked first pass hepatic metabolism. Incorporation in SLN, targeted to lymph after enteral administration may create a sustained release delivery system. This could maintain a prolonged blood concentration, and allow cellular internalization independent from MT1/MT2 membrane receptors.
Settore MED/41 - Anestesiologia
Pharmacokinetics of oral melatonin in high-risk critically ill : standard formulation vs incapsulation in solid lipid nanoparticles (SLN) / B. Salihovic, F. Ferrari, G. Mistraletti, E. Mantovani, R.C. Paroni, E. Finati, F.L. Fraschini, I Galluccio, B. Cerri, S. Marzorati, G. Iapichino. ((Intervento presentato al 23. convegno SMART tenutosi a Milano nel 2012.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/173725
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