Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the –SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.
Synthesis and antimalarial activities of some furoxan sulfones and related furazans / U. Galli, L. Lazzarato, M. Bertinaria, G. Sorba, A. Gasco, S. Parapini, D. Taramelli. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 40:12(2005 Jun), pp. 1335-1340. [10.1016/j.ejmech.2005.05.001]
Synthesis and antimalarial activities of some furoxan sulfones and related furazans
S. ParapiniPenultimo
;D. TaramelliUltimo
2005
Abstract
Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the –SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.
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