D-Glucose derivatives bearing an anomeric thiophenyl group and orthogonally protections on secondary hydroxyl groups were linked to solid supports (PS/DV polymer, tentagel resin) through an ester bond on C-6. It was investigated the possibility to remove orthogonally protecting groups and functionalize selectively the free hydroxyls groups and the anomeric carbon of sugars in solid phase.
D-glucose as a regioselectively addressable scaffold for combinatorial chemistry on solid phase / F. Peri, F. Nicotra, C.P. Leslie, F. Micheli, P. Seneci, C. Marchioro. - In: JOURNAL OF CARBOHYDRATE CHEMISTRY. - ISSN 0732-8303. - 22:1(2003), pp. 57-71. [10.1081/CAR-120019014]
D-glucose as a regioselectively addressable scaffold for combinatorial chemistry on solid phase
P. SeneciPenultimo
;
2003
Abstract
D-Glucose derivatives bearing an anomeric thiophenyl group and orthogonally protections on secondary hydroxyl groups were linked to solid supports (PS/DV polymer, tentagel resin) through an ester bond on C-6. It was investigated the possibility to remove orthogonally protecting groups and functionalize selectively the free hydroxyls groups and the anomeric carbon of sugars in solid phase.
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