Statins were shown to have neuroprotective effects, with reduced vasospasm and delayed ischemic deficits in statin-treated patients after aneurysmal subarachnoid hemorrhage in two small, randomized, controlled clinical trials published in 2005. This review consolidated data from available published studies evaluating statin treatment for subarachnoid hemorrhage. A literature search was conducted to identify original research studies published through October 2010 testing immediate treatment with a statin in statin-naïve patients following aneurysmal SAH. Six randomized controlled clinical trials and four observational studies were identified. Despite inconsistent results among studies, a meta-analysis of randomized controlled data showed a significant reduction in delayed ischemic deficits with statins. Effect on vasospasm was more difficult to determine, due to differences in definitions used among studies. Interpretations from observational studies were limited by the use of relatively small sample sizes, historical controls, and treatment variability.

Summary of evidence on immediate statins therapy following aneurysmal subarachnoid hemorrhage / M.Y. Tseng, M.N. Diringer, T.P. Bleck, N. Bruder, E.S. Connolly Jr, G. Citerio, D. Gress, D. Hanggi, J.C. Hemphill, B. Hoh, G. Lanzino, P. Le Roux, D. Menon, A. Rabinstein, E. Schmutzhard, L. Shutter, N. Stocchetti, J. Suarez, M. Treggiari, M.D. Vergouwen, P. Vespa, S. Wolf, G.J. Zipfel. - In: NEUROCRITICAL CARE. - ISSN 1541-6933. - 15:2(2011 Oct), pp. 298-301. [10.1007/s12028-011-9596-6]

Summary of evidence on immediate statins therapy following aneurysmal subarachnoid hemorrhage

N. Stocchetti;
2011

Abstract

Statins were shown to have neuroprotective effects, with reduced vasospasm and delayed ischemic deficits in statin-treated patients after aneurysmal subarachnoid hemorrhage in two small, randomized, controlled clinical trials published in 2005. This review consolidated data from available published studies evaluating statin treatment for subarachnoid hemorrhage. A literature search was conducted to identify original research studies published through October 2010 testing immediate treatment with a statin in statin-naïve patients following aneurysmal SAH. Six randomized controlled clinical trials and four observational studies were identified. Despite inconsistent results among studies, a meta-analysis of randomized controlled data showed a significant reduction in delayed ischemic deficits with statins. Effect on vasospasm was more difficult to determine, due to differences in definitions used among studies. Interpretations from observational studies were limited by the use of relatively small sample sizes, historical controls, and treatment variability.
Delayed ischemic deficits; Function; Pravastatin; Simvastatin; Vasospasm
Settore MED/41 - Anestesiologia
Settore MED/05 - Patologia Clinica
ott-2011
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/169577
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