A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active.
Studies on the novel anti-staphyloccal compound nematophin / G. Kennedy, M. Viziano, J.A. Winders, P. Cavallini, M. Gevi, F. Micheli, P. Rodegher, P. Seneci, A. Zumerle. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 10:15(2000 Aug 07), pp. 1751-1754. [10.1016/S0960-894X(00)00331-0]
Studies on the novel anti-staphyloccal compound nematophin
P. SeneciPenultimo
;
2000
Abstract
A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active.
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