Background: To review our experience in infectious diseases diagnosis, using a simple labelling technique. Methods: We made 101 scans in 91 patients with suspected infectious diseases confirmed by clinical, histologic or cultural specimens; a clinical or instrumental follow-up was available for every patient. Patients were divided into four subgroups: A: Inflammatory Bowel Diseases; B: Septic Syndromes; C: Bone diseases; D: Others. We used 99mTc-HMPAO in 80 scans and 111In in 21.In 20/80 frozen and stored HMPAO was used. Results: 99mTc-HMPAO frozen and stored labelling yield was: 60%(SD15%), 99mTcHMPAO: 62(12)(p n.s.), 111In 75%(10%), (p<0.05). Frozen-stored HMPAO was sterile and apyrogen. 27 had positive scan without leukocytosis or neutrophilia. No correlation between leukocytosis or neutrophilia and yield was observed. Transit lung times ranged between 14-16 min without differences among three radiopharmaceuticals. In each Group and in the sample as a whole True Positive, False Positive, True Negative, False Negative, Sensitivity, Specificity and Accuracy, were calculated. In Group B and in the sample as a whole Predictive Positive Value and Negative Predictive Value were also evaluated. Conclusions: Labelling yields and ''viability'' were good using the three radiopharmaceuticals; labelling procedure was simple and safe. Accuracy PPV, NPV, cost-effectiveness were good; 111In is the choice for diagnosis of bone and joint infections. Frozen-stored HMPAO should be introduced as a cost-saving labelling procedure in practice.
Labelled leukocytes for diagnosis of infectious diseases. Our experience in labelling and clinical usefulness / L. Tagliabue, C. Maioli, U. Pajoro, M. Musarra, C. Di Leo, A.S. Del Sole, A. Bestetti, G.L. Tarolo. - In: MINERVA MEDICA. - ISSN 0026-4806. - 91:11-12(2000 Nov), pp. 267-274.
|Titolo:||Labelled leukocytes for diagnosis of infectious diseases. Our experience in labelling and clinical usefulness|
MAIOLI, CLAUDIO (Secondo)
BESTETTI, ALBERTO (Penultimo)
TAROLO, GIAN LUIGI (Ultimo)
|Parole Chiave:||Exametazime diagnostic use; Indium radioisotopes diagnostic use; Infectious diseases; Leukocytes, radonuclide imaging; Technetium Tc99m|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
|Data di pubblicazione:||nov-2000|
|Appare nelle tipologie:||01 - Articolo su periodico|