A series of analogs of the natural antifungal compound crassinervic acid, a constituent of Piper crassinervium, were synthetized to gain insight into the most relevant structural features affecting the activity of the parent molecule. Most compounds were prepared by aldol reaction of methyl 3-acetyl-4-hydroxybenzoate with a series of ketones, followed by reduction, hydrolysis, and oxidation. The antifungal activitiesof crassinervic acid and its analogs was assessed against Cladosporium cladosporioides by using the method of bioautography. The bioassay results allowed us to depict structure-activity relationships for this class of compounds.
Synthesis and structure : activity relationships of antifungal crassinervic acid analogs / J.N. Chakor, L. Musso, P. Sardi, S. Dallavalle. - In: CHEMISTRY & BIODIVERSITY. - ISSN 1612-1872. - 9:1(2012 Jan), pp. 41-47.
Synthesis and structure : activity relationships of antifungal crassinervic acid analogs
J.N. ChakorPrimo
;L. MussoSecondo
;P. SardiPenultimo
;S. DallavalleUltimo
2012
Abstract
A series of analogs of the natural antifungal compound crassinervic acid, a constituent of Piper crassinervium, were synthetized to gain insight into the most relevant structural features affecting the activity of the parent molecule. Most compounds were prepared by aldol reaction of methyl 3-acetyl-4-hydroxybenzoate with a series of ketones, followed by reduction, hydrolysis, and oxidation. The antifungal activitiesof crassinervic acid and its analogs was assessed against Cladosporium cladosporioides by using the method of bioautography. The bioassay results allowed us to depict structure-activity relationships for this class of compounds.Pubblicazioni consigliate
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