We aimed testing feasibility of identification of regional left ventricular (LV) endocardial motion abnormalities in mice undergoing coronary ligation (MI), using cine magnetic resonance with retrospective gating and computation of regional fractional area change (RFAC), by comparison with histological "gold standard" evaluation. ROC analysis determined the optimal RFAC cut-off values for detecting regional ischemic injury. This approach was tested on 18 MI and 10 sham mice. Automated regional LV motion interpretation and bulls eye display allowed non-invasive localization of the induced infarction. Possible applications to future studies assessing the effectiveness of pharmacological treatments or regenerative medicine are expected.

Feasibility of quantitative analysis of regional left ventricular function in the post-infarct mouse by magnetic resonance imaging with retrospective gating / M. Franzosi, U. Guerrini, L. Castiglioni, L. Sironi, E. Nobili, E. Tremoli, E.G. Caiani. - In: COMPUTERS IN BIOLOGY AND MEDICINE. - ISSN 0010-4825. - 41:9(2011 Sep), pp. 829-837. [10.1016/j.compbiomed.2011.06.021]

Feasibility of quantitative analysis of regional left ventricular function in the post-infarct mouse by magnetic resonance imaging with retrospective gating

M. Franzosi
Primo
;
U. Guerrini
Secondo
;
L. Castiglioni;L. Sironi;E. Nobili;E. Tremoli
Penultimo
;
2011

Abstract

We aimed testing feasibility of identification of regional left ventricular (LV) endocardial motion abnormalities in mice undergoing coronary ligation (MI), using cine magnetic resonance with retrospective gating and computation of regional fractional area change (RFAC), by comparison with histological "gold standard" evaluation. ROC analysis determined the optimal RFAC cut-off values for detecting regional ischemic injury. This approach was tested on 18 MI and 10 sham mice. Automated regional LV motion interpretation and bulls eye display allowed non-invasive localization of the induced infarction. Possible applications to future studies assessing the effectiveness of pharmacological treatments or regenerative medicine are expected.
Myocardial infarction; Mice model; Left ventricle regional analysis; Magnetic resonance imaging; Retrospective gating; Regional fractional area change
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/166922
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