A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE ε4 allele resulted in a global p value of 0.56.
Failure to Replicate an Association of rs5984894 SNP in the PCDH11X Gene in a Collection of 1,222 Alzheimer's Disease Affected Patients / F. Lescai, C. Pirazzini, G. D'Agostino, A. Santoro, R. Ghidoni, L. Benussi, D. Galimberti, E. Federica, F. Marchegiani, M. Cardelli, F. Olivieri, B. Nacmias, S. Sorbi, S. Bagnoli, F. Tagliavini, D. Albani, F.M. Boneschi, G. Binetti, G. Forloni, P. Quadri, E. Scarpini, C. Franceschi. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 21:2(2010), pp. 385-388. [10.3233/JAD-2010-091516]
Failure to Replicate an Association of rs5984894 SNP in the PCDH11X Gene in a Collection of 1,222 Alzheimer's Disease Affected Patients
D. Galimberti;E. Scarpini;
2010
Abstract
A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE ε4 allele resulted in a global p value of 0.56.
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