Background and objective: Familial clusters of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have been reported. This study evaluates the history of cancer in BE patients families. Methods: In two years, patients with BE (272), esophagitis (456) and controls (517) were recruited in 12 Italian Endoscopy Units. Cancer family history in first-degree (FD) relatives was determined by a questionnaire. Results: Approximately 53% of BE, 51% of esophagitis, and 48% of controls had at least one relative affected by any type of malignancy. Probands with at least one esophageal or gastric (E/G) cancer-affected relative showed a BE risk which was at least eighty-five percent higher than that of probands without affected relatives. The relative risk of BE was 4.18, 95% CL = 0.76-23.04 if a FD relative had early (mean age <= 50 years) onset E/G cancer compared to late onset E/G cancer. Conclusion: In this sample there was no evidence that a family history of cancer was associated with the diagnosis of BE. An intriguing result was the association between the occurrence of E/G cancers at earlier ages (< 50 years) among BE relatives with respect the control group. This could suggest a genetic contribution in onset of these tumors, but the sample was too small to demonstrate a significant association. Further exploration of family history of E/G cancer and a diagnosis of BE in larger samples is warranted.
History of cancer in first degree relatives of Barrett's esophagus patients : a case-control study / A. De Ceglie, R. Filiberti, A. Blanchi, V. Fontana, D.A. Fisher, E. Grossi, T. Lacchin, M. De Matthaeis, O. Ignomirelli, R. Cappiello, D. Della Casa, M. Foti, F. Laterza, R. Rosati, V. Annese, G. Iaquinto, M. Conio. - In: CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY. - ISSN 2210-7401. - 35:12(2011 Dec), pp. 831-838. [10.1016/j.clinre.2011.07.015]
History of cancer in first degree relatives of Barrett's esophagus patients : a case-control study
R. Rosati;
2011
Abstract
Background and objective: Familial clusters of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have been reported. This study evaluates the history of cancer in BE patients families. Methods: In two years, patients with BE (272), esophagitis (456) and controls (517) were recruited in 12 Italian Endoscopy Units. Cancer family history in first-degree (FD) relatives was determined by a questionnaire. Results: Approximately 53% of BE, 51% of esophagitis, and 48% of controls had at least one relative affected by any type of malignancy. Probands with at least one esophageal or gastric (E/G) cancer-affected relative showed a BE risk which was at least eighty-five percent higher than that of probands without affected relatives. The relative risk of BE was 4.18, 95% CL = 0.76-23.04 if a FD relative had early (mean age <= 50 years) onset E/G cancer compared to late onset E/G cancer. Conclusion: In this sample there was no evidence that a family history of cancer was associated with the diagnosis of BE. An intriguing result was the association between the occurrence of E/G cancers at earlier ages (< 50 years) among BE relatives with respect the control group. This could suggest a genetic contribution in onset of these tumors, but the sample was too small to demonstrate a significant association. Further exploration of family history of E/G cancer and a diagnosis of BE in larger samples is warranted.Pubblicazioni consigliate
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