Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls (P=0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-morbidity for substance use disorders (SUDs).
Further evidence supporting the association between 5HTR2C gene and bipolar disorder / M. Mazza, L. Mandelli, G. Martinotti, M. Di Nicola, D. Tavian, G. Negri, E. Colombo, S. Missaglia, D. De Ronchi, R. Colombo, L. Janiri, A. Serretti. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 180:2-3(2010 Dec 30), pp. 151-152.
Further evidence supporting the association between 5HTR2C gene and bipolar disorder
G. Negri;E. Colombo;
2010
Abstract
Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls (P=0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-morbidity for substance use disorders (SUDs).
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