Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls (P=0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-morbidity for substance use disorders (SUDs).

Further evidence supporting the association between 5HTR2C gene and bipolar disorder / M. Mazza, L. Mandelli, G. Martinotti, M. Di Nicola, D. Tavian, G. Negri, E. Colombo, S. Missaglia, D. De Ronchi, R. Colombo, L. Janiri, A. Serretti. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 180:2-3(2010 Dec 30), pp. 151-152.

Further evidence supporting the association between 5HTR2C gene and bipolar disorder

G. Negri;E. Colombo;
2010-12-30

Abstract

Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls (P=0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-morbidity for substance use disorders (SUDs).
Genetic Linkage ; Young Adult ; Polymorphism, Single Nucleotide ; Gene Frequency ; Bipolar Disorder ; Humans ; Aged ; Genotype ; Receptor, Serotonin, 5-HT2C ; Aged, 80 and over ; Adult ; Substance-Related Disorders ; Middle Aged ; Adolescent ; Female ; Male
Settore BIO/11 - Biologia Molecolare
Settore BIO/18 - Genetica
Settore M-PSI/02 - Psicobiologia e Psicologia Fisiologica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/164850
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