Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of d beta thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto-maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.
ICSH recommendations for the measurement of haemoglobin F / A.D. Stephens, M. Angastiniotis, E. Baysal, V. Chan, B. Davis, S. Fucharoen, P.C. Giordano, J.D. Hoyer, A. Mosca, B. Wild. - In: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY. - ISSN 1751-5521. - 34:1(2012 Feb), pp. 14-20.
ICSH recommendations for the measurement of haemoglobin F
A. MoscaPenultimo
;
2012
Abstract
Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of d beta thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto-maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.
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