Aims To evaluate the long-lasting immunogenicity and safety of a pandemic vaccine co-administered with a seasonal influenza vaccine in young subjects with Type 1 diabetes. Methods Eighty patients (mean age: 16.7 +/- 5.5 years, disease duration: 10.2 +/- 4.7 years) were randomly assigned to receive a single or a double dose (1 month apart) of MF59-adjuvanted influenza A(H1N1) vaccine, simultaneously with a single dose of a virosome-adjuvanted trivalent influenza vaccine for the 20092010 season. Results One month after immunization, the rate of seroconversion to 2009 pandemic A(H1N1) was 92.5% with an overall 100% proportion of vaccinees with protective antibody titres (= 1:40). No significant differences were observed between vaccinees who received the one-dose or the two-dose schedule. Seasonal vaccine induced a significant increase of both seroprotection rates and antibody levels. Local adverse events at the injection site of pandemic and seasonal vaccines were reported by 66.3% and 50% of subjects, respectively. Solicited systemic adverse events, mainly mild in intensity, were reported by 26.7% of vaccinees. No subjects had an influenza-like illness during the 6-month follow-up. Conclusions One injection of 2009 pandemic influenza A(H1N1) MF59-adjuvanted vaccine is immunogenic and safe in young patients with Type 1 diabetes who are at increased risk of influenza morbidities. Pandemic vaccine can be safely co-administered with seasonal influenza vaccine.
Long-lasting immunogenicity and safety of a 2009 pandemic influenza A(H1N1) MF59-adjuvanted vaccine when co-administered with a 2009-2010 seasonal influenza vaccine in young patients with Type 1 diabetes mellitus / G.V. Zuccotti, E. Pariani, A. Scaramuzza, L. Santoro, E. Giani, M. Macedoni, A. Gazzarri, G. Anselmi, A. Amendola, A.R. Zanetti. - In: DIABETIC MEDICINE. - ISSN 0742-3071. - 28:12(2011 Dec), pp. 1530-1536.
|Titolo:||Long-lasting immunogenicity and safety of a 2009 pandemic influenza A(H1N1) MF59-adjuvanted vaccine when co-administered with a 2009-2010 seasonal influenza vaccine in young patients with Type 1 diabetes mellitus|
ZUCCOTTI, GIAN VINCENZO (Primo)
PARIANI, ELENA (Secondo)
AMENDOLA, ANTONELLA (Penultimo)
ZANETTI, ALESSANDRO REMO (Ultimo)
|Parole Chiave:||H1N1 vaccine ; immunogenicity ; influenza vaccine ; safety ; Type 1 diabetes|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
Settore MED/38 - Pediatria Generale e Specialistica
|Data di pubblicazione:||dic-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1464-5491.2011.03449.x|
|Appare nelle tipologie:||01 - Articolo su periodico|