A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis / X. Liu, P. Invernizzi, Y. Lu, R. Kosoy, Y. Lu, I. Bianchi, M. Podda, C. Xu, G. Xie, F. Macciardi, C. Selmi, S. Lupoli, R. Shigeta, M. Ransom, A. Lleo, A.T. Lee, A.L. Mason, R.P. Myers, K.M. Peltekian, C.N. Ghent, F. Bernuzzi, M. Zuin, F. Rosina, E. Borghesio, A. Floreani, R. Lazzari, G. Niro, A. Andriulli, L. Muratori, P. Muratori, P.L. Almasio, P. Andreone, M. Margotti, M. Brunetto, B. Coco, D. Alvaro, M.C. Bragazzi, F. Marra, A. Pisano, C. Rigamonti, M. Colombo, M. Marzioni, A. Benedetti, L. Fabris, M. Strazzabosco, P. Portincasa, V.O. Palmieri, C. Tiribelli, L. Croce, S. Bruno, S. Rossi, M. Vinci, C. Prisco, A. Mattalia, P. Toniutto, A. Picciotto, A. Galli, C. Ferrari, S. Colombo, G. Casella, L. Morini, N. Caporaso, A. Colli, G. Spinzi, R. Montanari, P.K. Gregersen, E.J. Heathcote, G.M. Hirschfield, K.A. Siminovitch, C.I. Amos, M.E. Gershwin, M.F. Seldin. - In: NATURE GENETICS. - ISSN 1061-4036. - 42:8(2010 Aug), pp. 658-660. [10.1038/ng.627]
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
F. Macciardi;C. Selmi;S. Lupoli;M. Zuin;
2010
Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).
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