α-Galactoglycosphingolipids (α-GalGSLs) are unique immunostimulatory glycosphingolipids from marine sponges. Analysis of the glycosphingolipid composition of the marine sponge Axinella damicornis revealed the presence of a new α-GalGSL, damicoside (3a), which is the first α-GalGSL with a glycosylated galactose 4-OH group. Structure elucidation of damicoside was performed using spectroscopic and chemical methods. When tested in a spleen cell proliferation assay, 3a exhibited a stimulatory activity comparable to that of agelasphin (2), showing that a free galactose 4-OH group is not essential for the immunostimulatory activity of α-GalGSLs and providing a further step toward the complete understanding of their structure-activity relationship.
|Titolo:||Damicoside from Axinella damicornis : the influence of a glycosylated galactose 4-OH group on the immunostimulatory activity of a-galactoglycosphingolipids|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||10.1021/jm050506y|
|Appare nelle tipologie:||01 - Articolo su periodico|