BACKGROUND & AIMS: The biological role of fatty acids (FA) in the perinatal period is under active investigation. We here describe the application of a simplified microanalytical procedure to compare the FA profile of maternal, umbilical cord and infant whole blood, inclusive of all circulating lipid fractions and cells. METHODS: The FA composition has been analyzed with a micromethod in 16 triplets, including maternal blood, cord blood at delivery and infant blood at day 4, respectively. RESULTS: As expected, the FA composition of blood samples withdrawn from the umbilical cord is more similar to the FA composition of blood from 4-day old infants than the FA pattern of maternal blood at delivery. Nevertheless, infant blood FA profile differed from cord for lower long-chain polyunsaturated FA and higher monounsaturated FA. CONCLUSIONS: Our explorative data using whole blood microanalysis confirm the progressive increase of long-chain polyunsaturated FA levels from the mothers towards cord and then infant blood.
Whole blood fatty acid composition at birth : From the maternal compartment to the infant / C. Agostoni, C. Galli, E. Riva, P. Risè, C. Colombo, M. Giovannini, F. Marangoni. - In: CLINICAL NUTRITION. - ISSN 0261-5614. - 30:4(2011 Aug), pp. 503-505.
Whole blood fatty acid composition at birth : From the maternal compartment to the infant
C. Agostoni;C. Galli;E. Riva;P. Risè;M. Giovannini;
2011
Abstract
BACKGROUND & AIMS: The biological role of fatty acids (FA) in the perinatal period is under active investigation. We here describe the application of a simplified microanalytical procedure to compare the FA profile of maternal, umbilical cord and infant whole blood, inclusive of all circulating lipid fractions and cells. METHODS: The FA composition has been analyzed with a micromethod in 16 triplets, including maternal blood, cord blood at delivery and infant blood at day 4, respectively. RESULTS: As expected, the FA composition of blood samples withdrawn from the umbilical cord is more similar to the FA composition of blood from 4-day old infants than the FA pattern of maternal blood at delivery. Nevertheless, infant blood FA profile differed from cord for lower long-chain polyunsaturated FA and higher monounsaturated FA. CONCLUSIONS: Our explorative data using whole blood microanalysis confirm the progressive increase of long-chain polyunsaturated FA levels from the mothers towards cord and then infant blood.File | Dimensione | Formato | |
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