The aim of this work was to examine the effects of long-term dietary administration of clenbuterol on fasting and post-feeding plasma cAMP and corticosterone in rabbits, in order to ascertain if its role as anti-inflammatory and growth promoting agent is mediated by modulations of their plasma concentrations. Eighteen 2-kg male New Zealand White rabbits, divided into 2 homogenous groups, were fed a control diet or a control diet plus 1 mg/kg clenbuterol for 31 d, ad libitum from 18.00 h to 09.00 h. Blood was withdrawn at the end of the experimental period at 18.00 h to 09.00 h and analyzed by RIA. The data related to plasma were processed by two-way ANOVA in order to evaluate the effects of treatment and feeding state. Treatment increased the mean daily gain (+34 %; P<0.001) and reduced feed conversion ratio (-22 %; P=0.001). Clenbuterol did not influence post-feeding (09.00 h) nor fasting (18.00 h) plasma cAMP, but increased fasting corticosterone (26.8 vs 41.2 µg/l; SE=6.3, P<0.05). In control group plasma cAMP was correlated (P<0.01) to corticosterone (post-feeding r=+0.754; fasting r=–0.714), but in treated animals cAMP was correlated to corticosterone only in post-feeding state (r=+0.67, P<0.05). Results show that the long-term β-agonist treatment raised fasting plasma corticosterone and that the higher levels did not actually affect plasma cAMP. Moreover, the treatment impaired the link between plasma cAMP and corticosterone, observed during fasting in the control group.

Effect of long-term β-agonist treatment on cAMP and corticosterone levels / F. Rosi, D. Magistrelli, C. Corino. - In: ITALIAN JOURNAL OF ANIMAL SCIENCE. - ISSN 1594-4077. - 10:suppl. 1(2011), pp. 106-106. ((Intervento presentato al 19. convegno ASPA tenutosi a Cremona nel 2011.

Effect of long-term β-agonist treatment on cAMP and corticosterone levels

F. Rosi;D. Magistrelli;C. Corino
2011

Abstract

The aim of this work was to examine the effects of long-term dietary administration of clenbuterol on fasting and post-feeding plasma cAMP and corticosterone in rabbits, in order to ascertain if its role as anti-inflammatory and growth promoting agent is mediated by modulations of their plasma concentrations. Eighteen 2-kg male New Zealand White rabbits, divided into 2 homogenous groups, were fed a control diet or a control diet plus 1 mg/kg clenbuterol for 31 d, ad libitum from 18.00 h to 09.00 h. Blood was withdrawn at the end of the experimental period at 18.00 h to 09.00 h and analyzed by RIA. The data related to plasma were processed by two-way ANOVA in order to evaluate the effects of treatment and feeding state. Treatment increased the mean daily gain (+34 %; P<0.001) and reduced feed conversion ratio (-22 %; P=0.001). Clenbuterol did not influence post-feeding (09.00 h) nor fasting (18.00 h) plasma cAMP, but increased fasting corticosterone (26.8 vs 41.2 µg/l; SE=6.3, P<0.05). In control group plasma cAMP was correlated (P<0.01) to corticosterone (post-feeding r=+0.754; fasting r=–0.714), but in treated animals cAMP was correlated to corticosterone only in post-feeding state (r=+0.67, P<0.05). Results show that the long-term β-agonist treatment raised fasting plasma corticosterone and that the higher levels did not actually affect plasma cAMP. Moreover, the treatment impaired the link between plasma cAMP and corticosterone, observed during fasting in the control group.
rabbit ; beta-agonist ; cAMP ; corticosterone
Settore VET/01 - Anatomia degli Animali Domestici
Settore AGR/18 - Nutrizione e Alimentazione Animale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/158334
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