Objective: To study the immunochemical distribution of Rantes chemokine and its correlation with HIV-p24 expression, in brains with HIV-related lesions. Material and methods: 17 HIV-positive cases of HIV-related brain lesions, 7 HIV-positive cases without cerebral HIV-related lesions (5 with opportunistic brain diseases), and 7 HIV-negative cases as controls (4 with brain lesion) were selected. Results: High expression of Rantes was observed in the cases with inflammatory brain lesions (22/24 HIV-positive and 2/7 HIV-negative patients). Positivity was observed in the diffuse and nodular microglial cells and lymphocytes. In the patients with HIV-related lesions, the presence of Rantes-stained microglia did not correlate with that of HIV-p24-positive cells. Positive astrocytes were only found in the HIV-positive patients. Multinucleated giant cells were always Rantes-negative. Conclusions: Our results seem to demonstrate the role of Rantes chemokine in inducing inflammatory brain perivascular and microglial reactions both in HIV-positive and -negative patients.

Rantes distribution and cellular localization in the brain of HIV-infected patients / L. Vago, M. Nebuloni, S. Bonetto, A. Pellegrinelli, P. Zerbi, A. Ferri, E. Lavri, M. Capra, M.P. Grassi, G. Costanzi. - In: CLINICAL NEUROPATHOLOGY. - ISSN 0722-5091. - 20:4(2001), pp. 139-145.

Rantes distribution and cellular localization in the brain of HIV-infected patients

L. Vago
Primo
;
M. Nebuloni
Secondo
;
A. Pellegrinelli;P. Zerbi;A. Ferri;G. Costanzi
Ultimo
2001

Abstract

Objective: To study the immunochemical distribution of Rantes chemokine and its correlation with HIV-p24 expression, in brains with HIV-related lesions. Material and methods: 17 HIV-positive cases of HIV-related brain lesions, 7 HIV-positive cases without cerebral HIV-related lesions (5 with opportunistic brain diseases), and 7 HIV-negative cases as controls (4 with brain lesion) were selected. Results: High expression of Rantes was observed in the cases with inflammatory brain lesions (22/24 HIV-positive and 2/7 HIV-negative patients). Positivity was observed in the diffuse and nodular microglial cells and lymphocytes. In the patients with HIV-related lesions, the presence of Rantes-stained microglia did not correlate with that of HIV-p24-positive cells. Positive astrocytes were only found in the HIV-positive patients. Multinucleated giant cells were always Rantes-negative. Conclusions: Our results seem to demonstrate the role of Rantes chemokine in inducing inflammatory brain perivascular and microglial reactions both in HIV-positive and -negative patients.
Central nervous system; Chemokines; HIV; Rantes
Settore MED/08 - Anatomia Patologica
Settore MED/26 - Neurologia
2001
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/157761
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