The IgG subclasses were investigated in children with febrile convulsions (FC) and in their first degree relatives in the search for a selective immunological deficiency associated with FC and its occurrence in the relatives of affected subjects. The results of the study show lower IgG2 concentrations in FC patients than in controls. But it was not possible to demonstrate familial transmission of the IgG2 subclass deficiency, since it was present only in children with FC and tended to normalize in adulthood. The immunoglobulin subclass deficiency might be responsible for the recurrent infections connected with FC.

IgG deficiency in children with febrile convulsions : a familial study / C. Lenti, C. Masserini, A. Barlocco, C. Peruzzi, A. Morabito. - In: ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES. - ISSN 0392-0461. - 14:7(1993), pp. 561-564.

IgG deficiency in children with febrile convulsions : a familial study

C. Lenti
Primo
;
C. Masserini
Secondo
;
A. Morabito
Ultimo
1993

Abstract

The IgG subclasses were investigated in children with febrile convulsions (FC) and in their first degree relatives in the search for a selective immunological deficiency associated with FC and its occurrence in the relatives of affected subjects. The results of the study show lower IgG2 concentrations in FC patients than in controls. But it was not possible to demonstrate familial transmission of the IgG2 subclass deficiency, since it was present only in children with FC and tended to normalize in adulthood. The immunoglobulin subclass deficiency might be responsible for the recurrent infections connected with FC.
Settore MED/25 - Psichiatria
Settore MED/39 - Neuropsichiatria Infantile
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/157491
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