Background and objective : Hepatitis C virus (HCV) infection is frequent in HIV-positive subjects. We evaluated the potential impact of HCV coinfection and other determinants on HIV disease progression in a cohort of long-term non-progressors (LTNPs). Study design : We studied immunological and virological factors in a cohort of 49 LTNPs, 23 of whom progressed during the follow-up (late progressors; LPs). Results : HCV coinfection was detected in 19/26 LTNPs and 15/23 LPs. Univariate analysis showed that HIV viral load was associated with disease progression (P=0.04), and time-to-event analysis indicated that HCV genotype 1 significantly correlated with LTNP status (P=0.031). At multivariate analysis, HIV viremia at study entry remained independently associated with LTNP status (P=0.049). When the most represented genotypes (1 and 3a) were considered in the model, genotype 3a infection (P=0.034) and gender (P=0.035) emerged as independent variables related to HIV disease progression, whereas HIV viral load disappeared. Conclusions : In addition to HIV viremia, coinfection with different HCV genotypes and gender may affect LTNP status

Hepatitis C virus (HCV) coinfection in a cohort of HIV positive long-term non-progressors : possible protective effect of infecting HCV genotype on HIV disease progression / G. Morsica, S. Bagaglio, S. Ghezzi, C. Lodrini, E. Vicenzi, E. Santagostino, A. Gringeri, M. Cusini, G. Carminati, G. Bianchi, L. Galli, A. Lazzarin, G. Poli. - In: JOURNAL OF CLINICAL VIROLOGY. - ISSN 1386-6532. - 39:2(2007 Jun), pp. 82-86.

Hepatitis C virus (HCV) coinfection in a cohort of HIV positive long-term non-progressors : possible protective effect of infecting HCV genotype on HIV disease progression

S. Bagaglio;S. Ghezzi;C. Lodrini;A. Gringeri;L. Galli;A. Lazzarin;
2007-06

Abstract

Background and objective : Hepatitis C virus (HCV) infection is frequent in HIV-positive subjects. We evaluated the potential impact of HCV coinfection and other determinants on HIV disease progression in a cohort of long-term non-progressors (LTNPs). Study design : We studied immunological and virological factors in a cohort of 49 LTNPs, 23 of whom progressed during the follow-up (late progressors; LPs). Results : HCV coinfection was detected in 19/26 LTNPs and 15/23 LPs. Univariate analysis showed that HIV viral load was associated with disease progression (P=0.04), and time-to-event analysis indicated that HCV genotype 1 significantly correlated with LTNP status (P=0.031). At multivariate analysis, HIV viremia at study entry remained independently associated with LTNP status (P=0.049). When the most represented genotypes (1 and 3a) were considered in the model, genotype 3a infection (P=0.034) and gender (P=0.035) emerged as independent variables related to HIV disease progression, whereas HIV viral load disappeared. Conclusions : In addition to HIV viremia, coinfection with different HCV genotypes and gender may affect LTNP status
HIV disease progression ; LTNPs ; HCV genotype ; HIV load
Settore MED/09 - Medicina Interna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/157069
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