Despite improved knowledge of clinical, laboratory and molecular markers recently obtained for inherited von Willebrand disease (VWD), current laboratory diagnosis of different VWD types is still a major problem in many countries. Several guidelines for the phenotypic diagnosis of VWD have been published, but the recommendations proposed have largely been developed through consensus of experts in the field. Only recently have criteria for evidence-based diagnosis in VWD type 1 been proposed. This study was designed to determine the best laboratory repertoire currently available for VWD diagnosis, using a different approach. For the first time, lyophilized plasma samples derived from patients with known VWD types and mutations were tested blindly and prospectively in a worldwide network of laboratories.

Laboratory diagnosis of von Willebrand disease: results from a prospective and blind study in 32 laboratories worldwide using lyophilized plasmas / C.A. Lee, A. Hubbard, C.A. Sabin, U. Budde, G. Castaman, E.J. Favaloro, K.D. Friedman, A.B. Federici. - In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. - ISSN 1538-7933. - 9:1(2011 Jan), pp. 220-222.

Laboratory diagnosis of von Willebrand disease: results from a prospective and blind study in 32 laboratories worldwide using lyophilized plasmas

A.B. Federici
Ultimo
2011

Abstract

Despite improved knowledge of clinical, laboratory and molecular markers recently obtained for inherited von Willebrand disease (VWD), current laboratory diagnosis of different VWD types is still a major problem in many countries. Several guidelines for the phenotypic diagnosis of VWD have been published, but the recommendations proposed have largely been developed through consensus of experts in the field. Only recently have criteria for evidence-based diagnosis in VWD type 1 been proposed. This study was designed to determine the best laboratory repertoire currently available for VWD diagnosis, using a different approach. For the first time, lyophilized plasma samples derived from patients with known VWD types and mutations were tested blindly and prospectively in a worldwide network of laboratories.
Settore MED/15 - Malattie del Sangue
gen-2011
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/155733
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