Murine SEL-1L (mSEL-1L), a key component of the endoplasmic reticulum associated degradation (ERAD) pathway, is essential during mouse embryonic development as revealed by multi-organ dysfunction and subsequent in uterus lethality occurring in mSEL-1L knock-outs. mSEL-1L is highly expressed in mouse embryonic stem cells, during neural commitment and in mature stem cells (NSCs) but completely absent during astrocyte, oligodendrocyte and neuron differentiation. Interestingly, mSEL-1L protein depletion in differentiated neural stem cells and in mouse adult brain is partly due to activation of mmu-miR-183, a microRNA able to suppress the expression of stem cell factors. We hypothesize that mSEL-1L is an “embryonic stemness marker” that could influence neurogenesis and gliogenesis cell fate determination by establishing a specific micro-environment that coordinates stem cells self-renewing and differentiation.
Murine SEL-1L, a gene implicated in the ERAD pathway, is expressed in mouse embryo stem cells and is controlled by mmu-miR-183 during neural stem cell differentiation / M. Cardano, G. Diaferia, S.S. Dessì, C.C. Spinelli, L. Conti, E. Cattaneo, P. De Blasio, I. Biunno. ((Intervento presentato al 2. convegno NeuroStemcell annual meeting tenutosi a Bellagio nel 2010.
Murine SEL-1L, a gene implicated in the ERAD pathway, is expressed in mouse embryo stem cells and is controlled by mmu-miR-183 during neural stem cell differentiation
M. CardanoPrimo
;G. DiaferiaSecondo
;C.C. Spinelli;L. Conti;E. Cattaneo;
2010
Abstract
Murine SEL-1L (mSEL-1L), a key component of the endoplasmic reticulum associated degradation (ERAD) pathway, is essential during mouse embryonic development as revealed by multi-organ dysfunction and subsequent in uterus lethality occurring in mSEL-1L knock-outs. mSEL-1L is highly expressed in mouse embryonic stem cells, during neural commitment and in mature stem cells (NSCs) but completely absent during astrocyte, oligodendrocyte and neuron differentiation. Interestingly, mSEL-1L protein depletion in differentiated neural stem cells and in mouse adult brain is partly due to activation of mmu-miR-183, a microRNA able to suppress the expression of stem cell factors. We hypothesize that mSEL-1L is an “embryonic stemness marker” that could influence neurogenesis and gliogenesis cell fate determination by establishing a specific micro-environment that coordinates stem cells self-renewing and differentiation.Pubblicazioni consigliate
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