Polyhydroxylated hybrid molecules have been synthesized using a protocol based on the regioselective acylation of the target compounds with activated dicarboxylic acids catalyzed by Novozym-435. The procedure implies that the mixed ester derivatives prepared and isolated from the first esterification step act as acylating agents in the second esterification step.
Exploiting enzymatic regioselectivity : a facile methodology for the synthesis of polyhydroxylated hybrid compounds / P. Magrone, F. Cavallo, W. Panzeri, D. Passarella, S. Riva. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 8:24(2010), pp. 5583-5590. [10.1039/c0ob00304b]
Exploiting enzymatic regioselectivity : a facile methodology for the synthesis of polyhydroxylated hybrid compounds
P. Magrone;D. Passarella;
2010
Abstract
Polyhydroxylated hybrid molecules have been synthesized using a protocol based on the regioselective acylation of the target compounds with activated dicarboxylic acids catalyzed by Novozym-435. The procedure implies that the mixed ester derivatives prepared and isolated from the first esterification step act as acylating agents in the second esterification step.Pubblicazioni consigliate
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