The authors treated 10 patients with multifocal motor neuropathy (MMN) responding to an initial course of IV immunoglobulin (IVIg) with periodic infusion for 5 to 12 years (mean 8.2 years). At last follow-up, only two patients had maintained the maximal improvement achieved during therapy while eight worsened despite increasing Ig dosage. This decline started after 3 to 7 years (mean 4.8 years) of therapy and correlated with a reduction of distal compound muscle action potential amplitudes (p < 0.019). The effectiveness of IVIg in MMN often declines after several years possibly associated with the development of axonal degeneration.
|Titolo:||How-long is IVIg effective in multifocal motor neuropathy?|
|Autori interni:||NOBILE-ORAZIO, EDUARDO|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||10.1212/01.WNL.0000110185.23464.A1|
|Appare nelle tipologie:||01 - Articolo su periodico|