A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check its participation in the coordinating process. New isoxazole-based histone deacetylase inhibitors structurally related to SAHA were designed and synthesized to check the participation of the isoxazole moiety in the Zn 2+coordination.
Design and synthesis of novel isoxazole-based HDAC inhibitors / P. Conti, L. Tamborini, A. Pinto, L. Sola, R. Ettari, C. Mercurio, C. De Micheli. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 45:9(2010 Sep), pp. 4331-4338.
Titolo: | Design and synthesis of novel isoxazole-based HDAC inhibitors |
Autori: | CONTI, PAOLA (Primo) TAMBORINI, LUCIA (Secondo) DE MICHELI, CARLO (Ultimo) |
Settore Scientifico Disciplinare: | Settore CHIM/08 - Chimica Farmaceutica |
Data di pubblicazione: | set-2010 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ejmech.2010.06.035 |
Appare nelle tipologie: | 01 - Articolo su periodico |