A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check its participation in the coordinating process. New isoxazole-based histone deacetylase inhibitors structurally related to SAHA were designed and synthesized to check the participation of the isoxazole moiety in the Zn 2+coordination.
Design and synthesis of novel isoxazole-based HDAC inhibitors / P. Conti, L. Tamborini, A. Pinto, L. Sola, R. Ettari, C. Mercurio, C. De Micheli. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 45:9(2010 Sep), pp. 4331-4338.
|Titolo:||Design and synthesis of novel isoxazole-based HDAC inhibitors|
CONTI, PAOLA (Primo)
TAMBORINI, LUCIA (Secondo)
DE MICHELI, CARLO (Ultimo)
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||set-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejmech.2010.06.035|
|Appare nelle tipologie:||01 - Articolo su periodico|