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EnglishThe three-dimensional histology technique is used in human medicine for the evaluation of complete lateral and deep surgical margins. In this study, the technique was applied to 48 excised feline injection-site sarcoma specimens. The predictive value of the histological margin status and tumour grading on local recurrence was investigated. In 32/48 cases, the margins were non-infiltrated, whilst in the remaining 16 cases, they were infiltrated. Overall, 6/32 (19%) tumours with non-infiltrated margins and 11/16 (69%) with infiltrated margins recurred. Tumours with infiltrated margins recurred about 10 times more frequently compared to tumours with non-infiltrated margins (P=0.0011). No statistically significant correlation was observed between grading and recurrence. The assessment of margin status using the 3D histology technique showed a good predictivity for post-surgical tumour recurrence. Extensive application of the 3D histology technique is recommended to standardise the evaluation of histological margins and to allow comparison between results from different laboratories
Feline injection-site sarcoma : recurrence, tumour grading and surgical margin status evaluated using the three-dimensional histological technique / C. Giudice, D. Stefanello, M. Sala, M. Cantatore, F. Russo, S. Romussi, O. Travetti, M. Di Giancamillo, V. Grieco. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 186:1(2010 Oct), pp. 84-88. [10.1016/j.tvjl.2009.07.019]
| Titolo: | Feline injection-site sarcoma : recurrence, tumour grading and surgical margin status evaluated using the three-dimensional histological technique | |
| Autori: | ||
| Parole Chiave: | Feline; Histopathology; Margins; Sarcoma; Three-dimensional histology | |
| Settore Scientifico Disciplinare: | Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria Settore VET/09 - Clinica Chirurgica Veterinaria | |
| Data di pubblicazione: | ott-2010 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.tvjl.2009.07.019 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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|---|---|---|---|---|
| 2010_FIIS_vetjournal.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
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