The multi-step preparation of N-Boc-3,4-dehydro-L-proline methyl ester using a modular flow reactor is reported. The use of immobilised reagents and scavengers in pre-packed glass tubes allows us to obtain the pure product in 87% overall yield, 97% purity, and >98% enantiomeric excess without any additional purification step. Our flow-based protocol enables the rapid multi-gram synthesis (about 9 g/12 h) of the desired product.
A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-L-proline methyl ester / L. Tamborini, P. Conti, A. Pinto, C. De Micheli. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 21:2(2010 Feb), pp. 222-225.
Titolo: | A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-L-proline methyl ester |
Autori: | TAMBORINI, LUCIA (Primo) CONTI, PAOLA (Secondo) PINTO, ANDREA (Penultimo) DE MICHELI, CARLO (Ultimo) |
Settore Scientifico Disciplinare: | Settore CHIM/08 - Chimica Farmaceutica |
Data di pubblicazione: | feb-2010 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.tetasy.2009.12.023 |
Appare nelle tipologie: | 01 - Articolo su periodico |