This report describes an efficient synthesis of the natural isomer of acivicin, which is the only one provided with a noteworthy biological activity. The present procedure allowed the synthesis of (+)-1 in just five steps with a 34% overall yield. Due to the easy separation of the two diastereomers and to the availability of the starting material at low cost, the present procedure can be scaled-up to gram quantities.
A novel simplified synthesis of Acivicin / A. Pinto, P. Conti, L. Tamborini, C. De Micheli. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 20:4(2009 Mar 11), pp. 508-511. [10.1016/j.tetasy.2009.02.010]
A novel simplified synthesis of Acivicin
A. PintoPrimo
;P. Conti
Secondo
;L. TamboriniPenultimo
;C. De MicheliUltimo
2009
Abstract
This report describes an efficient synthesis of the natural isomer of acivicin, which is the only one provided with a noteworthy biological activity. The present procedure allowed the synthesis of (+)-1 in just five steps with a 34% overall yield. Due to the easy separation of the two diastereomers and to the availability of the starting material at low cost, the present procedure can be scaled-up to gram quantities.
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