Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value
Chemokines and chemokine receptors : an overview / R. Bonecchi, E.R. Galliera, E.M. Borroni, M.M. Corsi, M. Locati, A. Mantovani. - In: FRONTIERS IN BIOSCIENCE. - ISSN 1093-9946. - 14:2(2009 Jan), pp. 540-551. [10.2741/3261]
Chemokines and chemokine receptors : an overview
R. BonecchiPrimo
;E.R. GallieraSecondo
;E.M. Borroni;M.M. Corsi;M. LocatiPenultimo
;A. MantovaniUltimo
2009
Abstract
Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value
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