Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value

Chemokines and chemokine receptors : an overview / R. Bonecchi, E.R. Galliera, E.M. Borroni, M.M. Corsi, M. Locati, A. Mantovani. - In: FRONTIERS IN BIOSCIENCE. - ISSN 1093-9946. - 14:2(2009 Jan), pp. 540-551.

Chemokines and chemokine receptors : an overview

R. Bonecchi
Primo
;
E.R. Galliera
Secondo
;
E.M. Borroni;M.M. Corsi;M. Locati
Penultimo
;
A. Mantovani
Ultimo
2009-01

Abstract

Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value
Chemokine; Chemokine receptor; Inflammation; Review
Settore MED/04 - Patologia Generale
Settore MED/05 - Patologia Clinica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/142827
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