In a study designed to determine ceftibuten concentrations in tonsillar tissue, subjects scheduled to undergo tonsillectomy were administered 400 mg of ceftibuten in a single oral dose. Between 2 and 24 h after the dose was given, tonsillar tissue samples were taken during surgery and assayed for ceftibuten. Mean concentrations in tonsillar tissue 4.4 h and 24.6 h after the 400 mg dose were 5.3 ± 2.7 and 0.3 ± 0.3 mg/g, respectively. Concurrent mean serum concentrations were 7.42 ± 1.66 and 0.15 ± 0.13 mg/ml, respectively. The apparent half-life of drug in the tissue was 5.3 h. The presence of high ceftibuten concentrations in tonsillar tissue suggests that a once-daily regimen may be effective in treating tonsillitis and pharyngitis.

Ceftibuten concentrations in human tonsillar tissue / F. Scaglione, J.P. Pintucci, G. Demartini, S. Dugnani. - In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. - ISSN 0934-9723. - 15:12(1996), pp. 940-943.

Ceftibuten concentrations in human tonsillar tissue

F. Scaglione
Primo
;
G. Demartini
Penultimo
;
S. Dugnani
Ultimo
1996

Abstract

In a study designed to determine ceftibuten concentrations in tonsillar tissue, subjects scheduled to undergo tonsillectomy were administered 400 mg of ceftibuten in a single oral dose. Between 2 and 24 h after the dose was given, tonsillar tissue samples were taken during surgery and assayed for ceftibuten. Mean concentrations in tonsillar tissue 4.4 h and 24.6 h after the 400 mg dose were 5.3 ± 2.7 and 0.3 ± 0.3 mg/g, respectively. Concurrent mean serum concentrations were 7.42 ± 1.66 and 0.15 ± 0.13 mg/ml, respectively. The apparent half-life of drug in the tissue was 5.3 h. The presence of high ceftibuten concentrations in tonsillar tissue suggests that a once-daily regimen may be effective in treating tonsillitis and pharyngitis.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/141098
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