In a study designed to determine ceftibuten concentrations in tonsillar tissue, subjects scheduled to undergo tonsillectomy were administered 400 mg of ceftibuten in a single oral dose. Between 2 and 24 h after the dose was given, tonsillar tissue samples were taken during surgery and assayed for ceftibuten. Mean concentrations in tonsillar tissue 4.4 h and 24.6 h after the 400 mg dose were 5.3 ± 2.7 and 0.3 ± 0.3 mg/g, respectively. Concurrent mean serum concentrations were 7.42 ± 1.66 and 0.15 ± 0.13 mg/ml, respectively. The apparent half-life of drug in the tissue was 5.3 h. The presence of high ceftibuten concentrations in tonsillar tissue suggests that a once-daily regimen may be effective in treating tonsillitis and pharyngitis.
Ceftibuten concentrations in human tonsillar tissue / F. Scaglione, J.P. Pintucci, G. Demartini, S. Dugnani. - In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. - ISSN 0934-9723. - 15:12(1996), pp. 940-943.
|Titolo:||Ceftibuten concentrations in human tonsillar tissue|
SCAGLIONE, FRANCESCO (Primo)
DEMARTINI, GERMANA (Penultimo)
DUGNANI, SILVANA (Ultimo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1996|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF01690513|
|Appare nelle tipologie:||01 - Articolo su periodico|