The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards perturbation. A recent paper published in BMC Biology shows how the founder domains of known cancer genes emerged at two macroevolutionary transitions - the advent of the first cell and the transition to metazoan multicellularity.
The (r)evolution of cancer genetics / F. Ciccarelli. - In: BMC BIOLOGY. - ISSN 1741-7007. - 8:(2010 Jun 11), pp. 74.1-74.4. [10.1186/1741-7007-8-74]
The (r)evolution of cancer genetics
F. Ciccarelli
2010
Abstract
The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards perturbation. A recent paper published in BMC Biology shows how the founder domains of known cancer genes emerged at two macroevolutionary transitions - the advent of the first cell and the transition to metazoan multicellularity.
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