A versatile electrochemical method for the intramolecular aminobromination of alkenes has been developed. The method provides access to five-, six-, and seven-membered heterocycles by exploiting tetrabutylammonium bromide as an electrolyte and bromine source. The mild electrochemical generation of Br2 plausibly allows the formation of a cyclic bromonium intermediate, as supported by density functional theory calculations.
Electrochemical Intramolecular Aminobromination of Alkenes / S. Colombo, E. Cartamina, M. Papis, D. Spanu, L. Lo Presti, G. Macetti, G. Poli, A. Contini, G. Broggini, C. Loro. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1099-0690. - 29:2(2026 Jan 16), pp. e202500808.1-e202500808.5. [10.1002/ejoc.202500808]
Electrochemical Intramolecular Aminobromination of Alkenes
L. Lo Presti;G. Macetti;A. Contini;
2026
Abstract
A versatile electrochemical method for the intramolecular aminobromination of alkenes has been developed. The method provides access to five-, six-, and seven-membered heterocycles by exploiting tetrabutylammonium bromide as an electrolyte and bromine source. The mild electrochemical generation of Br2 plausibly allows the formation of a cyclic bromonium intermediate, as supported by density functional theory calculations.
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