Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts

Kals, M.; Wilson, L.; Levey, D.F.; Parodi, L.; Steyerberg, E.W.; Richardson, S.; He, F.; Sun, X.; Jain, S.; Palotie, A.; Ripatti, S.; Rosand, J.; Manley, G.T.; Maas, A.I.R.; Stein, M.B.; Menon, D.K.; Ackerlund, C.; Adams, H.; Amrein, K.; Andelic, N.; Andreassen, L.; Anke, A.; Antoni, A.; Audibert, G.; Azouvi, P.; Azzolini, M.L.; Bartels, R.; Barzo, P.; Beauvais, R.; Beer, R.; Bellander, B.-.; Belli, A.; Benali, H.; Berardino, M.; Beretta, L.; Blaabjerg, M.; Bragge, P.; Brazinova, A.; Brinck, V.; Brooker, J.; Brorsson, C.; Buki, A.; Bullinger, M.; Cabeleira, M.; Caccioppola, A.; Calappi, E.; Calvi, M.R.; Cameron, P.; Lozano, G.C.; Carbonara, M.; Castano-Leon, A.M.; Cavallo, S.; Chevallard, G.; Chieregato, A.; Citerio, G.; Clusmann, H.; Coburn, M.S.; Coles, J.; Cooper, J.D.; Correia, M.; Covic, A.; Curry, N.; Czeiter, E.; Czosnyka, M.; Dahyot-Fizelier, C.; Dark, P.; Dawes, H.; De Keyser, V.; Degos, V.; Della Corte, F.; Boogert, H.D.; Depreitere, B.; Dilvesi,; Dixit, A.; Donoghue, E.; Dreier, J.; Duliere, G.-.; Ercole, A.; Esser, P.; Ezer, E.; Fabricius, M.; Feigin, V.L.; Foks, K.; Frisvold, S.; Furmanov, A.; Gagliardo, P.; Galanaud, D.; Gantner, D.; Gao, G.; George, P.; Ghuysen, A.; Giga, L.; Glocker, B.; Golubovic, J.; Gomez, P.A.; Gratz, J.; Gravesteijn, B.; Grossi, F.; Gruen, R.L.; Gupta, D.; Haagsma, J.A.; Haitsma, I.; Helbok, R.; Helseth, E.; Horton, L.; Huijben, J.; Hutchinson, P.J.; Jacobs, B.; Jankowski, S.; Jarrett, M.; Jiang, J.-.; Johnson, F.; Jones, K.; Karan, M.; Kolias, A.G.; Kompanje, E.; Kondziella, D.; Koskinen, L.-.; Kovacs, N.; Kowark, A.; Lagares, A.; Lanyon, L.; Laureys, S.; Lecky, F.; Ledoux, D.; Lefering, R.; Legrand, V.; Lejeune, A.; Levi, L.; Lightfoot, R.; Lingsma, H.; Maegele, M.; Majdan, M.; Manara, A.; Marechal, H.; Martino, C.; Mattern, J.; Mcfadyen, C.; Mcmahon, C.; Melegh, B.; Menovsky, T.; Mikolic, A.; Misset, B.; Muraleedharan, V.; Murray, L.; Negru, A.; Nelson, D.; Newcombe, V.; Nieboer, D.; Nyiradi, J.; Oresic, M.; Ortolano, F.; Otesile, O.; Parizel, P.M.; Payen, J.-.; Perera, N.; Perlbarg, V.; Persona, P.; Peul, W.; Piippo-Karjalainen, A.; Pirinen, M.; Pisica, D.; Ples, H.; Polinder, S.; Pomposo, I.; Posti, J.P.; Puybasset, L.; Radoi, A.; Ragauskas, A.; Raj, R.; Rambadagalla, M.; Rehorcikova, V.; Helmrich, I.R.; Rhodes, J.; Richter, S.; Rocka, S.; Roe, C.; Roise, O.; Rosenfeld, J.; Rosenlund, C.; Rosenthal, G.; Rossaint, R.; Rossi, S.; Rueckert, D.; Rusnak, M.; Sahuquillo, J.; Sakowitz, O.; Sanchez-Porras, R.; Sandor, J.; Schafer, N.; Schmidt, S.; Schoechl, H.; Schoonman, G.; Schou, R.F.; Schwendenwein, E.; Sewalt, C.; Singh, R.D.; Skandsen, T.; Smielewski, P.; Sorinola, A.; Stamatakis, E.; Stanworth, S.; Stevens, R.; Stewart, W.; Stocchetti, N.; Sundstrom, N.; Takala, R.; Tamas, V.; Tamosuitis, T.; Taylor, M.S.; Te Ao, B.; Tenovuo, O.; Theadom, A.; Thibaut, A.; Thomas, M.; Tibboel, D.; Timmers, M.; Tolias, C.; Trapani, T.; Tudora, C.M.; Unterberg, A.; Vajkoczy, P.; Valeinis, E.; Vallance, S.; Vamos, Z.; Van Der Jagt, M.; Van Der Naalt, J.; Van Der Steen, G.; Van Dijck, J.T.J.M.; Van Erp, I.A.; Van Essen, T.A.; Van Hecke, W.; Van Heugten, C.; Van Praag, D.; Van Veen, E.; Van Wijk, R.; Vyvere, T.V.; Vargiolu, A.; Vega, E.; Velt, K.; Verheyden, J.; Vespa, P.M.; Vik, A.; Vilcinis, R.; Volovici, V.; Von Steinbuchel, N.; Voormolen, D.; Vulekovic, P.; Whitehouse, D.; Wiegers, E.; Williams, G.; Wolf, S.; Yang, Z.; Ylen, P.; Younsi, A.; Zeiler, F.A.; Ziverte, A.; Zoerle, T.; Adeoye, O.; Badjatia, N.; Barber, J.; Bergin, M.; Boase, K.; Bodien, Y.; Chesnut, R.; Corrigan, J.; Crawford, K.; Diaz-Arrastia, R.; Dikmen, S.; Duhaime, A.-.; Ellenbogen, R.; Feeser, V.; Ferguson, A.R.; Foreman, B.; Gaudette, E.; Giacino, J.; Gonzalez, L.; Gopinath, S.; Grandhi, R.; Gullapalli, R.; Hemphill, C.; Hotz, G.; Huie, R.; Jha, R.; Keene, D.C.; Kitagawa, R.; Korley, F.; Kramer, J.; Kreitzer, N.; Levin, H.; Lindsell, C.; Machamer, J.; Madden, C.; Martin, A.; Mcallister, T.; Mccrea, M.; Merchant, R.; Mukherjee, P.; Nelson, L.; Ngwenya, L.B.; Noel, F.; Nolan, A.; Okonkwo, D.; Palacios, E.; Perl, D.; Puccio, A.; Rabinowitz, M.; Robertson, C.; Ben Rodgers, R.; Rosenthal, E.; Sander, A.; Sandsmark, D.; Schneider, A.; Schnyer, D.; Seabury, S.; Sherer, M.; Sugar, G.; Temkin, N.; Toga, A.; Torres-Espin, A.; Valadka, A.; Vassar, M.; Wang, K.; Wang, V.; Yue, J.K.; Yuh, E.; Zafonte, R.

doi:10.1016/j.eclinm.2024.102956

Background Post-traumatic stress disorder (PTSD) and depression are common after mild traumatic brain injury (mTBI), but their biological drivers are uncertain. We therefore explored whether polygenic risk scores (PRS) derived for PTSD and major depressive disorder (MDD) are associated with the development of cognate TBI-related phenotypes. Methods Meta-analyses were conducted using data from two multicenter, prospective observational cohort studies of patients with mTBI: the CENTER-TBI study (ClinicalTrials.gov ID NCT02210221) in Europe (December 2014- December 2017) and the TRACK-TBI study in the US (March 2014-July 2018). In both cohorts, the most common causes of injury were road traffic accidents and falls. Primary outcomes, specifically probable PTSD and depression, were defined at 6 months post-injury using scores >= 33 on the PTSD Checklist-5 and >= 15 on the Patient Health Questionnaire-9, respectively. We calculated PTSD-PRS and MDD-PRS for patients aged >= 17 years who had a Glasgow Coma Scale score of 13-15 upon hospital arrival and assessed their association with PTSD and depression following TBI. We also evaluated the transferability of the findings in a cohort of African Americans. Findings Overall, 11.8% (219/1869) and 6.7% (124/1869) patients were classified as having probable PTSD and depression, respectively. The PTSD-PRS was significantly associated with higher adjusted odds of PTSD in both cohorts, with a pooled odds ratio (OR) of 1.55 [95% confidence interval (CI) 1.30-1.84, p < 0.001, I2 = 20.8%]. Although the MDD-PRS increased the risk of depression after TBI, it did not reach significance in the individual cohorts. However, in a combined analysis, the risk was significantly elevated with a pooled OR of 1.26 [95% CI 1.03-1.53, p = 0.02, I2 = 0%]. The addition of PRSs improved the proportion of outcome variance explained in the two study cohorts from 19.5% and 30.3% to 21.6% and 34.0% for PTSD; and from 11.0% and 22.5% to 12.8% and 22.6% for depression. Patients in the highest cognate PRS quintile had increased odds of 3.16 [95% CI 1.80-5.55] and 2.03 [95% CI 1.04-3.94] of developing PTSD or depression compared to the lowest quintile, respectively. Interpretation Associations of PRSs with PTSD and depression following TBI are not disorder-specific. However, the overlap between MDD-PRS and depression following TBI is less robust compared to PTSD-PRS and PTSD. PRSs could improve risk prediction, and permit enrichment for interventional trials.

Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts / M. Kals, L. Wilson, D.F. Levey, L. Parodi, E.W. Steyerberg, S. Richardson, F. He, X. Sun, S. Jain, A. Palotie, S. Ripatti, J. Rosand, G.T. Manley, A.I.R. Maas, M.B. Stein, D.K. Menon, C. Ackerlund, H. Adams, K. Amrein, N. Andelic, L. Andreassen, A. Anke, A. Antoni, G. Audibert, P. Azouvi, M.L. Azzolini, R. Bartels, P. Barzo, R. Beauvais, R. Beer, B.-. Bellander, A. Belli, H. Benali, M. Berardino, L. Beretta, M. Blaabjerg, P. Bragge, A. Brazinova, V. Brinck, J. Brooker, C. Brorsson, A. Buki, M. Bullinger, M. Cabeleira, A. Caccioppola, E. Calappi, M.R. Calvi, P. Cameron, G.C. Lozano, M. Carbonara, A.M. Castano-Leon, S. Cavallo, G. Chevallard, A. Chieregato, G. Citerio, H. Clusmann, M.S. Coburn, J. Coles, J.D. Cooper, M. Correia, A. Covic, N. Curry, E. Czeiter, M. Czosnyka, C. Dahyot-Fizelier, P. Dark, H. Dawes, V. De Keyser, V. Degos, F. Della Corte, H.D. Boogert, B. Depreitere, Dilvesi, A. Dixit, E. Donoghue, J. Dreier, G.-. Duliere, A. Ercole, P. Esser, E. Ezer, M. Fabricius, V.L. Feigin, K. Foks, S. Frisvold, A. Furmanov, P. Gagliardo, D. Galanaud, D. Gantner, G. Gao, P. George, A. Ghuysen, L. Giga, B. Glocker, J. Golubovic, P.A. Gomez, J. Gratz, B. Gravesteijn, F. Grossi, R.L. Gruen, D. Gupta, J.A. Haagsma, I. Haitsma, R. Helbok, E. Helseth, L. Horton, J. Huijben, P.J. Hutchinson, B. Jacobs, S. Jankowski, M. Jarrett, J.-. Jiang, F. Johnson, K. Jones, M. Karan, A.G. Kolias, E. Kompanje, D. Kondziella, L.-. Koskinen, N. Kovacs, A. Kowark, A. Lagares, L. Lanyon, S. Laureys, F. Lecky, D. Ledoux, R. Lefering, V. Legrand, A. Lejeune, L. Levi, R. Lightfoot, H. Lingsma, M. Maegele, M. Majdan, A. Manara, H. Marechal, C. Martino, J. Mattern, C. Mcfadyen, C. Mcmahon, B. Melegh, T. Menovsky, A. Mikolic, B. Misset, V. Muraleedharan, L. Murray, A. Negru, D. Nelson, V. Newcombe, D. Nieboer, J. Nyiradi, M. Oresic, F. Ortolano, O. Otesile, P.M. Parizel, J.-. Payen, N. Perera, V. Perlbarg, P. Persona, W. Peul, A. Piippo-Karjalainen, M. Pirinen, D. Pisica, H. Ples, S. Polinder, I. Pomposo, J.P. Posti, L. Puybasset, A. Radoi, A. Ragauskas, R. Raj, M. Rambadagalla, V. Rehorcikova, I.R. Helmrich, J. Rhodes, S. Richter, S. Rocka, C. Roe, O. Roise, J. Rosenfeld, C. Rosenlund, G. Rosenthal, R. Rossaint, S. Rossi, D. Rueckert, M. Rusnak, J. Sahuquillo, O. Sakowitz, R. Sanchez-Porras, J. Sandor, N. Schafer, S. Schmidt, H. Schoechl, G. Schoonman, R.F. Schou, E. Schwendenwein, C. Sewalt, R.D. Singh, T. Skandsen, P. Smielewski, A. Sorinola, E. Stamatakis, S. Stanworth, R. Stevens, W. Stewart, N. Stocchetti, N. Sundstrom, R. Takala, V. Tamas, T. Tamosuitis, M.S. Taylor, B. Te Ao, O. Tenovuo, A. Theadom, A. Thibaut, M. Thomas, D. Tibboel, M. Timmers, C. Tolias, T. Trapani, C.M. Tudora, A. Unterberg, P. Vajkoczy, E. Valeinis, S. Vallance, Z. Vamos, M. Van Der Jagt, J. Van Der Naalt, G. Van Der Steen, J.T.J.M. Van Dijck, I.A. Van Erp, T.A. Van Essen, W. Van Hecke, C. Van Heugten, D. Van Praag, E. Van Veen, R. Van Wijk, T.V. Vyvere, A. Vargiolu, E. Vega, K. Velt, J. Verheyden, P.M. Vespa, A. Vik, R. Vilcinis, V. Volovici, N. Von Steinbuchel, D. Voormolen, P. Vulekovic, D. Whitehouse, E. Wiegers, G. Williams, S. Wolf, Z. Yang, P. Ylen, A. Younsi, F.A. Zeiler, A. Ziverte, T. Zoerle, O. Adeoye, N. Badjatia, J. Barber, M. Bergin, K. Boase, Y. Bodien, R. Chesnut, J. Corrigan, K. Crawford, R. Diaz-Arrastia, S. Dikmen, A.-. Duhaime, R. Ellenbogen, V. Feeser, A.R. Ferguson, B. Foreman, E. Gaudette, J. Giacino, L. Gonzalez, S. Gopinath, R. Grandhi, R. Gullapalli, C. Hemphill, G. Hotz, R. Huie, R. Jha, D.C. Keene, R. Kitagawa, F. Korley, J. Kramer, N. Kreitzer, H. Levin, C. Lindsell, J. Machamer, C. Madden, A. Martin, T. Mcallister, M. Mccrea, R. Merchant, P. Mukherjee, L. Nelson, L.B. Ngwenya, F. Noel, A. Nolan, D. Okonkwo, E. Palacios, D. Perl, A. Puccio, M. Rabinowitz, C. Robertson, R. Ben Rodgers, E. Rosenthal, A. Sander, D. Sandsmark, A. Schneider, D. Schnyer, S. Seabury, M. Sherer, G. Sugar, N. Temkin, A. Toga, A. Torres-Espin, A. Valadka, M. Vassar, K. Wang, V. Wang, J.K. Yue, E. Yuh, R. Zafonte. - In: ECLINICALMEDICINE. - ISSN 2589-5370. - 78:(2024), pp. 102956.1-102956.12. [10.1016/j.eclinm.2024.102956]

Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts

Kals M.;Wilson L.;Levey D. F.;L. Parodi;Steyerberg E. W.;Richardson S.;He F.;Sun X.;Jain S.;Palotie A.;Ripatti S.;Rosand J.;Manley G. T.;Maas A. I. R.;Stein M. B.;Menon D. K.;Ackerlund C.;Adams H.;Amrein K.;Andelic N.;Andreassen L.;Anke A.;Antoni A.;Audibert G.;Azouvi P.;Azzolini M. L.;Bartels R.;Barzo P.;Beauvais R.;Beer R.;Bellander B. -M.;Belli A.;Benali H.;Berardino M.;Beretta L.;Blaabjerg M.;Bragge P.;Brazinova A.;Brinck V.;Brooker J.;Brorsson C.;Buki A.;Bullinger M.;Cabeleira M.;A. Caccioppola;Calappi E.;Calvi M. R.;Cameron P.;Lozano G. C.;Carbonara M.;Castano-Leon A. M.;Cavallo S.;G. Chevallard;Chieregato A.;Citerio G.;Clusmann H.;Coburn M. S.;Coles J.;Cooper J. D.;Correia M.;Covic A.;Curry N.;Czeiter E.;Czosnyka M.;Dahyot-Fizelier C.;Dark P.;Dawes H.;De Keyser V.;Degos V.;Della Corte F.;Boogert H. D.;Depreitere B.;Dilvesi;Dixit A.;Donoghue E.;Dreier J.;Duliere G. -L.;Ercole A.;Esser P.;Ezer E.;Fabricius M.;Feigin V. L.;Foks K.;Frisvold S.;Furmanov A.;Gagliardo P.;Galanaud D.;Gantner D.;Gao G.;George P.;Ghuysen A.;Giga L.;Glocker B.;Golubovic J.;Gomez P. A.;Gratz J.;Gravesteijn B.;Grossi F.;Gruen R. L.;Gupta D.;Haagsma J. A.;Haitsma I.;Helbok R.;Helseth E.;Horton L.;Huijben J.;Hutchinson P. J.;Jacobs B.;Jankowski S.;Jarrett M.;Jiang J. -Y.;Johnson F.;Jones K.;Karan M.;Kolias A. G.;Kompanje E.;Kondziella D.;Koskinen L. -O.;Kovacs N.;Kowark A.;Lagares A.;Lanyon L.;Laureys S.;Lecky F.;Ledoux D.;Lefering R.;Legrand V.;Lejeune A.;L. Levi;Lightfoot R.;Lingsma H.;Maegele M.;Majdan M.;Manara A.;Marechal H.;Martino C.;Mattern J.;McFadyen C.;McMahon C.;Melegh B.;Menovsky T.;Mikolic A.;Misset B.;Muraleedharan V.;L. Murray;Negru A.;Nelson D.;Newcombe V.;Nieboer D.;Nyiradi J.;Oresic M.;F. Ortolano;Otesile O.;Parizel P. M.;Payen J. -F.;Perera N.;Perlbarg V.;Persona P.;Peul W.;Piippo-Karjalainen A.;Pirinen M.;Pisica D.;Ples H.;Polinder S.;Pomposo I.;Posti J. P.;Puybasset L.;Radoi A.;Ragauskas A.;Raj R.;Rambadagalla M.;Rehorcikova V.;Helmrich I. R.;Rhodes J.;Richter S.;Rocka S.;Roe C.;Roise O.;Rosenfeld J.;Rosenlund C.;Rosenthal G.;Rossaint R.;Rossi S.;Rueckert D.;Rusnak M.;Sahuquillo J.;Sakowitz O.;Sanchez-Porras R.;Sandor J.;Schafer N.;Schmidt S.;Schoechl H.;Schoonman G.;Schou R. F.;Schwendenwein E.;Sewalt C.;Singh R. D.;Skandsen T.;Smielewski P.;Sorinola A.;Stamatakis E.;Stanworth S.;Stevens R.;Stewart W.;N. Stocchetti;Sundstrom N.;Takala R.;Tamas V.;Tamosuitis T.;Taylor M. S.;Te Ao B.;Tenovuo O.;Theadom A.;Thibaut A.;Thomas M.;Tibboel D.;Timmers M.;Tolias C.;Trapani T.;Tudora C. M.;Unterberg A.;Vajkoczy P.;Valeinis E.;Vallance S.;Vamos Z.;van der Jagt M.;van der Naalt J.;Van der Steen G.;van Dijck J. T. J. M.;van Erp I. A.;van Essen T. A.;Van Hecke W.;van Heugten C.;Van Praag D.;van Veen E.;van Wijk R.;Vyvere T. V.;Vargiolu A.;Vega E.;Velt K.;Verheyden J.;Vespa P. M.;Vik A.;Vilcinis R.;Volovici V.;von Steinbuchel N.;Voormolen D.;Vulekovic P.;Whitehouse D.;Wiegers E.;Williams G.;Wolf S.;Yang Z.;Ylen P.;Younsi A.;Zeiler F. A.;Ziverte A.;T. Zoerle;Adeoye O.;Badjatia N.;Barber J.;Bergin M.;Boase K.;Bodien Y.;Chesnut R.;Corrigan J.;Crawford K.;Diaz-Arrastia R.;Dikmen S.;Duhaime A. -C.;Ellenbogen R.;Feeser V.;Ferguson A. R.;Foreman B.;Gaudette E.;Giacino J.;Gonzalez L.;Gopinath S.;Grandhi R.;Gullapalli R.;Hemphill C.;Hotz G.;Huie R.;Jha R.;Keene D. C.;Kitagawa R.;Korley F.;Kramer J.;Kreitzer N.;Levin H.;Lindsell C.;Machamer J.;Madden C.;A. Martin;McAllister T.;McCrea M.;Merchant R.;Mukherjee P.;Nelson L.;Ngwenya L. B.;Noel F.;Nolan A.;Okonkwo D.;Palacios E.;Perl D.;A. Puccio;Rabinowitz M.;Robertson C.;Ben Rodgers R.;Rosenthal E.;Sander A.;Sandsmark D.;Schneider A.;Schnyer D.;Seabury S.;Sherer M.;Sugar G.;Temkin N.;Toga A.;Torres-Espin A.;Valadka A.;Vassar M.;Wang K.;Wang V.;Yue J. K.;Yuh E.;Zafonte R.

2024

Abstract

Background Post-traumatic stress disorder (PTSD) and depression are common after mild traumatic brain injury (mTBI), but their biological drivers are uncertain. We therefore explored whether polygenic risk scores (PRS) derived for PTSD and major depressive disorder (MDD) are associated with the development of cognate TBI-related phenotypes. Methods Meta-analyses were conducted using data from two multicenter, prospective observational cohort studies of patients with mTBI: the CENTER-TBI study (ClinicalTrials.gov ID NCT02210221) in Europe (December 2014- December 2017) and the TRACK-TBI study in the US (March 2014-July 2018). In both cohorts, the most common causes of injury were road traffic accidents and falls. Primary outcomes, specifically probable PTSD and depression, were defined at 6 months post-injury using scores >= 33 on the PTSD Checklist-5 and >= 15 on the Patient Health Questionnaire-9, respectively. We calculated PTSD-PRS and MDD-PRS for patients aged >= 17 years who had a Glasgow Coma Scale score of 13-15 upon hospital arrival and assessed their association with PTSD and depression following TBI. We also evaluated the transferability of the findings in a cohort of African Americans. Findings Overall, 11.8% (219/1869) and 6.7% (124/1869) patients were classified as having probable PTSD and depression, respectively. The PTSD-PRS was significantly associated with higher adjusted odds of PTSD in both cohorts, with a pooled odds ratio (OR) of 1.55 [95% confidence interval (CI) 1.30-1.84, p < 0.001, I2 = 20.8%]. Although the MDD-PRS increased the risk of depression after TBI, it did not reach significance in the individual cohorts. However, in a combined analysis, the risk was significantly elevated with a pooled OR of 1.26 [95% CI 1.03-1.53, p = 0.02, I2 = 0%]. The addition of PRSs improved the proportion of outcome variance explained in the two study cohorts from 19.5% and 30.3% to 21.6% and 34.0% for PTSD; and from 11.0% and 22.5% to 12.8% and 22.6% for depression. Patients in the highest cognate PRS quintile had increased odds of 3.16 [95% CI 1.80-5.55] and 2.03 [95% CI 1.04-3.94] of developing PTSD or depression compared to the lowest quintile, respectively. Interpretation Associations of PRSs with PTSD and depression following TBI are not disorder-specific. However, the overlap between MDD-PRS and depression following TBI is less robust compared to PTSD-PRS and PTSD. PRSs could improve risk prediction, and permit enrichment for interventional trials.

Scheda breve

Scheda completa

Scheda completa (DC)

	Parole chiave
	
				Depression; Mental health; Polygenic risk score; Post-traumatic stress disorder; Traumatic brain injury
			
	Settori scientifico-disciplinari dell'articolo (validi dal 09/05/2024)
	
				Settore MEDS-23/A - Anestesiologia
			
	Titolo del progetto
	
	Titolo Progetto
	
									Collaborative European NeuroTrauma Effectiveness Research in TBI
								
	Acronimo
	
									CENTER-TBI
								
	Nome finanziatore
	
										European Commission
									
	Finanziamento
	
									SEVENTH FRAMEWORK PROGRAMME
								
	N. Contratto
	
									602150
								
	Titolo Progetto
	
									Investigating the Genomic Architecture of Anxiety and Overlap with Mental Health Disorders in the Million Veteran Program.
								
	Nome finanziatore
	
										National Institutes of Health
									
	Finanziamento
	
									VETERANS AFFAIRS
								
	N. Contratto
	
									1IK2BX005058-01A2
								
	Titolo Progetto
	
									TBI-REPORTER (UK-TBI REpository and data PORTal Enabling discoveRy)
								
	Nome finanziatore
	
										UK Research and Innovation
									
	Finanziamento
	
									MRC
								
	N. Contratto
	
									MR/Y008502/1
								
	Data di pubblicazione
	
				2024
			
	Rivista in ANCE
	
				ECLINICALMEDICINE
			
	DOI
	
				https://dx.doi.org/10.1016/j.eclinm.2024.102956
			
	Tipologia
	
				Article (author)
			
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				01 - Articolo su periodico

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