With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.
Clone competition as a mechanism to reduce tumor formation / A. Acha-Sagredo, I. Malanchi, F.D. Ciccarelli. - In: DEVELOPMENTAL CELL. - ISSN 1534-5807. - 56:24(2021 Dec 20), pp. 3307-3308. [10.1016/j.devcel.2021.12.003]
Clone competition as a mechanism to reduce tumor formation
F.D. Ciccarelli
Ultimo
2021
Abstract
With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.
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