Two metastable polymorphs of paracetamol (forms II and III) were prepared by appropriate thermal methods from binary mixtures containing 10% (w/w) of hydroxypropylmethylcellulose. By controlling the reheating step, it was possible to address the recrystallization of the drug either into form II or III. Moreover, it was observed that form III transforms either into form II or I depending on the preparation method. The physical characterization of the polymorphs was performed by means of micro-Fourier transform infrared spectroscopy (MFTIR) and powder X-ray diffractometry (PXRD), both temperature controlled
Solid-state characterization of paracetamol metastable polymorphs formed in binary mixtures with hydroxypropylmethylcellulose / A. Rossi, A. Savioli, M. Bini, D. Capsoni, V. Massarotti, R. Bettini, A. Gazzaniga, M.E. Sangalli, F. Giordano. - In: THERMOCHIMICA ACTA. - ISSN 0040-6031. - 406:1-2(2003), pp. 55-67. [10.1016/S0040-6031(03)00227-2]
Solid-state characterization of paracetamol metastable polymorphs formed in binary mixtures with hydroxypropylmethylcellulose
A. Gazzaniga;M.E. SangalliPenultimo
;
2003
Abstract
Two metastable polymorphs of paracetamol (forms II and III) were prepared by appropriate thermal methods from binary mixtures containing 10% (w/w) of hydroxypropylmethylcellulose. By controlling the reheating step, it was possible to address the recrystallization of the drug either into form II or III. Moreover, it was observed that form III transforms either into form II or I depending on the preparation method. The physical characterization of the polymorphs was performed by means of micro-Fourier transform infrared spectroscopy (MFTIR) and powder X-ray diffractometry (PXRD), both temperature controlled
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