The thermal behaviour of Diclofenac was investigated using Differential Scanning Calorimetry, Hot Stage Microscopy, and Thermogravimetric Analysis. A discrepancy was observed between the melting point values recorded under dynamic flow of either dry nitrogen (180°C) or air (160°C). By means of High Performance Liquid Chromatography/Mass Spectrometric analyses, it has been possible to ascribe this difference in melting points to the formation of three degradation products as a result of intramolecular cyclization and condensation reactions during the heating process in an oxidative atmosphere.
Thermal degradation and melting point determination of diclofenac / F. Giordano, A. Rossi, I. Pasquali, R. Bettini, E. Frigo, A. Gazzaniga, M.E. Sangalli, V. Mileo, S. Catinella. - In: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY. - ISSN 1388-6150. - 73:2(2003), pp. 509-518.
Thermal degradation and melting point determination of diclofenac
A. Gazzaniga;M.E. Sangalli;
2003
Abstract
The thermal behaviour of Diclofenac was investigated using Differential Scanning Calorimetry, Hot Stage Microscopy, and Thermogravimetric Analysis. A discrepancy was observed between the melting point values recorded under dynamic flow of either dry nitrogen (180°C) or air (160°C). By means of High Performance Liquid Chromatography/Mass Spectrometric analyses, it has been possible to ascribe this difference in melting points to the formation of three degradation products as a result of intramolecular cyclization and condensation reactions during the heating process in an oxidative atmosphere.
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