In this issue of Molecular Cell, Kiss et al.1 introduce UbiREAD, a technology that deciphers ubiquitin chain-mediated degradation in living cells, revealing a hierarchy where K48 chains of at least three ubiquitins drive rapid proteasomal degradation and branched K48/K63 chains follow substrate-anchored rules.
Deconstructing destruction: A rapid route to proteasomal fate / E. Maspero, S. Polo. - In: MOLECULAR CELL. - ISSN 1097-4164. - 85:7(2025 Apr 03), pp. 1255-1257. [10.1016/j.molcel.2025.03.011]
Deconstructing destruction: A rapid route to proteasomal fate
E. MasperoPrimo
;S. Polo
Ultimo
Conceptualization
2025
Abstract
In this issue of Molecular Cell, Kiss et al.1 introduce UbiREAD, a technology that deciphers ubiquitin chain-mediated degradation in living cells, revealing a hierarchy where K48 chains of at least three ubiquitins drive rapid proteasomal degradation and branched K48/K63 chains follow substrate-anchored rules.
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