INTRODUCTION:The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk.METHODS:A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).RESULTS:Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion.DISCUSSION:Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.
Early Antibody Dynamics in a Prospective Cohort of Children at Risk of Celiac Disease / F. Valitutti, M.M. Leonard, V. Kenyon, M. Montuori, P. Piemontese, R. Francavilla, B. Malamisura, L. Norsa, A. Calvi, M.E. Lionetti, M. Baldassarre, C.M. Trovato, M. Perrone, T. Passaro, N. Sansotta, M. Crocco, A. Morelli, L.C. Raguseo, F. Malerba, L. Elli, F. Cristofori, C. Catassi, A. Fasano. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 118:3(2023), pp. 574-577. [10.14309/ajg.0000000000002192]
Early Antibody Dynamics in a Prospective Cohort of Children at Risk of Celiac Disease
L. Norsa;M. Baldassarre;M. Crocco;L. Elli;
2023
Abstract
INTRODUCTION:The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk.METHODS:A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).RESULTS:Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion.DISCUSSION:Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.
| File | Dimensione | Formato | |
|---|---|---|---|
|
early_antibody_dynamics_in_a_prospective_cohort_of.39.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Licenza:
Nessuna licenza
Dimensione
239.33 kB
Formato
Adobe PDF
|
239.33 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
