The incidence of early-onset colorectal cancer (EO-CRC) is surging, and by 2030, one-third of all CRCs will occur before the commonly recommended screening age of 50 years. The time required for EO-CRC to reach the metastatic stage is unknown, yet this knowledge is critical to tailor early-diagnosis screening strategies. Here, we discuss how defining a key biological feature of EO-CRC may be central to protecting young adults from an alarming and probably unprecedented tumor epidemic.
Tumor "age" in early-onset colorectal cancer / G. Mauri, G. Patelli, G. Crisafulli, S. Siena, A. Bardelli. - In: CELL. - ISSN 1097-4172. - 188:3(2025), pp. 589-593. [10.1016/j.cell.2024.12.003]
Tumor "age" in early-onset colorectal cancer
G. MauriPrimo
;G. Patelli;S. SienaCo-ultimo
;
2025
Abstract
The incidence of early-onset colorectal cancer (EO-CRC) is surging, and by 2030, one-third of all CRCs will occur before the commonly recommended screening age of 50 years. The time required for EO-CRC to reach the metastatic stage is unknown, yet this knowledge is critical to tailor early-diagnosis screening strategies. Here, we discuss how defining a key biological feature of EO-CRC may be central to protecting young adults from an alarming and probably unprecedented tumor epidemic.
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