Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.
Normal Somatic Mutations in Cancer Transformation / N. Wijewardhane, L. Dressler, F.D. Ciccarelli. - In: CANCER CELL. - ISSN 1535-6108. - 39:2(2021), pp. 125-129. [10.1016/j.ccell.2020.11.002]
Normal Somatic Mutations in Cancer Transformation
F.D. Ciccarelli
Ultimo
2021
Abstract
Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.
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