FORMULAZIONE A RILASCIO PROLUNGATO A PERMANENZA GASTRICA A BASE DI NITROFURANTOINA

The present invention relates to a gastric-retention sustained-release Nitrofurantoin-based formulation. In particular, the present invention relates to a tablet consisting of two or more compartments, having different formulations, with at least one being Nitrofurantoin-based, wherein said formulation is in solid form. The formulation is in the form of a double-layered, three-layer or coated tablet, wherein one or more compartments contain the active ingredient Nitrofurantoin, while the other compartments do not contain the active ingredient. The combination of compartments, through the use of certain excipients, imparts swelling properties, with consequent increased retention at the gastric level, favoring the desired release profile. The formulation has been designed so as to obtain swelling at the gastric level, so as to prevent the tablet from transiting through the pylorus, in contact with biological fluids, thus favoring the retention of the formulation at the gastric level, for a sufficiently long period of time to ensure the desired absorption level of Nitrofurantoin.